Seroatlas · Human Serome Atlas

CAPN7

Calpain-7

Also known as: CAN7_HUMAN, PalBH

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6W3
Gene
CAPN7
Ensembl
ENSG00000131375
Chromosome
3
Canonical length
813 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Centrosome,Cytosol

OverviewNCBI Gene

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

813 residues, UniProt reviewed canonical sequence.

>Q9Y6W3|CAPN7
     1  MDATALERDA VQFARLAVQR DHEGRYSEAV FYYKEAAQAL IYAEMAGSSL ENIQEKITEY
    61  LERVQALHSA VQSKSADPLK SKHQLDLERA HFLVTQAFDE DEKENVEDAI ELYTEAVDLC
   121  LKTSYETADK VLQNKLKQLA RQALDRAEAL SEPLTKPVGK ISSTSVKPKP PPVRAHFPLG
   181  ANPFLERPQS FISPQSCDAQ GQRYTAEEIE VLRTTSKING IEYVPFMNVD LRERFAYPMP
   241  FCDRWGKLPL SPKQKTTFSK WVRPEDLTNN PTMIYTVSSF SIKQTIVSDC SFVASLAISA
   301  AYERRFNKKL ITGIIYPQNK DGEPEYNPCG KYMVKLHLNG VPRKVIIDDQ LPVDHKGELL
   361  CSYSNNKSEL WVSLIEKAYM KVMGGYDFPG SNSNIDLHAL TGWIPERIAM HSDSQTFSKD
   421  NSFRMLYQRF HKGDVLITAS TGMMTEAEGE KWGLVPTHAY AVLDIREFKG LRFIQLKNPW
   481  SHLRWKGRYS ENDVKNWTPE LQKYLNFDPR TAQKIDNGIF WISWDDLCQY YDVIYLSWNP
   541  GLFKESTCIH STWDAKQGPV KDAYSLANNP QYKLEVQCPQ GGAAVWVLLS RHITDKDDFA
   601  NNREFITMVV YKTDGKKVYY PADPPPYIDG IRINSPHYLT KIKLTTPGTH TFTLVVSQYE
   661  KQNTIHYTVR VYSACSFTFS KIPSPYTLSK RINGKWSGQS AGGCGNFQET HKNNPIYQFH
   721  IEKTGPLLIE LRGPRQYSVG FEVVTVSTLG DPGPHGFLRK SSGDYRCGFC YLELENIPSG
   781  IFNIIPSTFL PKQEGPFFLD FNSIIPIKIT QLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAPN7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • retina: 26 nTPM
  • skeletal muscle: 24 nTPM
  • thyroid gland: 22 nTPM
  • parathyroid gland: 19 nTPM
  • liver: 18 nTPM
  • cervix: 16 nTPM

Single-cell type

  • myonuclei: 272 nCPM
  • rod photoreceptor cells: 254 nCPM
  • lactotrophs: 242 nCPM
  • somatotrophs: 224 nCPM
  • pituicytes/fscs: 219 nCPM
  • adrenal cortex cells: 216 nCPM

Immune cell

  • MAIT T-cell: 5.3 nTPM
  • eosinophil: 5.1 nTPM
  • naive CD4 T-cell: 4.9 nTPM
  • basophil: 4.7 nTPM
  • naive CD8 T-cell: 4.7 nTPM
  • non-classical monocyte: 4.4 nTPM

Brain region

  • cerebellum: 32 nTPM
  • choroid plexus: 25 nTPM
  • white matter: 25 nTPM
  • hypothalamus: 23 nTPM
  • medulla oblongata: 19 nTPM
  • spinal cord: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CAPN7.

Disease | ImmuneIEDB

Conditions an epitope on CAPN7 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.79
gnomAD pLI
0
gnomAD missense Z
1.21
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAPN7 as an antibody target. Whether an autoantibody or antibody against CAPN7 could matter depends on whether native CAPN7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAPN7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAPN7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CAPN7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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