RPS6KC1

Protein identityUniProt · HPA

UniProt accession

Q96S38

Gene

RPS6KC1

Ensembl

ENSG00000136643

Chromosome

1

Canonical length

1066 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Endosomes,Lysosomes

OverviewNCBI Gene

Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

1066 residues, UniProt reviewed canonical sequence.

>Q96S38|RPS6KC1
     1  MTSYRERSAD LARFYTVTEP QRHPRGYTVY KVTARVVSRR NPEDVQEIIV WKRYSDFKKL
    61  HKELWQIHKN LFRHSELFPP FAKGIVFGRF DETVIEERRQ CAEDLLQFSA NIPALYNSKQ
   121  LEDFFKGGII NDSSELIGPA EAHSDSLIDT FPECSTEGFS SDSDLVSLTV DVDSLAELDD
   181  GMASNQNSPI RTFGLNLSSD SSALGAVASD SEQSKTEEER ESRSLFPGSL KPKLGKRDYL
   241  EKAGELIKLA LKKEEEDDYE AASDFYRKGV DLLLEGVQGE SSPTRREAVK RRTAEYLMRA
   301  ESISSLYGKP QLDDVSQPPG SLSSRPLWNL RSPAEELKAF RVLGVIDKVL LVMDTRTEQT
   361  FILKGLRKSS EYSRNRKTII PRCVPNMVCL HKYIISEESV FLVLQHAEGG KLWSYISKFL
   421  NRSPEESFDI KEVKKPTLAK VHLQQPTSSP QDSSSFESRG SDGGSMLKAL PLKSSLTPSS
   481  QDDSNQEDDG QDSSPKWPDS GSSSEEECTT SYLTLCNEYG QEKIEPGSLN EEPFMKTEGN
   541  GVDTKAIKSF PAHLAADSDS PSTQLRAHEL KFFPNDDPEA VSSPRTSDSL SRSKNSPMEF
   601  FRIDSKDSAS ELLGLDFGEK LYSLKSEPLK PFFTLPDGDS ASRSFNTSES KVEFKAQDTI
   661  SRGSDDSVPV ISFKDAAFDD VSGTDEGRPD LLVNLPGELE STREAAAMGP TKFTQTNIGI
   721  IENKLLEAPD VLCLRLSTEQ CQAHEEKGIE ELSDPSGPKS YSITEKHYAQ EDPRMLFVAA
   781  VDHSSSGDMS LLPSSDPKFQ GLGVVESAVT ANNTEESLFR ICSPLSGANE YIASTDTLKT
   841  EEVLLFTDQT DDLAKEEPTS LFQRDSETKG ESGLVLEGDK EIHQIFEDLD KKLALASRFY
   901  IPEGCIQRWA AEMVVALDAL HREGIVCRDL NPNNILLNDR GHIQLTYFSR WSEVEDSCDS
   961  DAIERMYCAP EVGAITEETE ACDWWSLGAV LFELLTGKTL VECHPAGINT HTTLNMPECV
  1021  SEEARSLIQQ LLQFNPLERL GAGVAGVEDI KSHPFFTPVD WAELMR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS6KC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.52

Highest tissue expression

18 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPS6KC1.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 381 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Neurodevelopmental disorder with spasticity, thin corpus callosum, and decreased brain white matter
• 6 conditions

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.48

gnomAD pLI

0

gnomAD missense Z

0.45

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• signal transduction

Molecular functions

• ATP binding
• phosphatidylinositol binding
• protein serine kinase activity
• protein serine/threonine kinase activity

Cellular components

• early endosome
• endosome
• lysosome
• membrane

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Phox homology
• MIT domain
• Protein kinase-like domain superfamily
• RPK118-like, kinase domain
• MIT domain superfamily
• PX domain superfamily
• Intracellular Signaling and Trafficking Protein
• Protein kinase domain
• PX domain
• MIT (microtubule interacting and transport) domain
• Ribosomal protein S6 kinase delta-1, PX domain

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Endosome
• Kinase
• Lipid-binding
• Membrane
• Nucleotide-binding
• Phosphoprotein
• Repeat
• Serine/threonine-protein kinase
• Transferase

InteractionsUniProt · HPA

Protein binding partners of RPS6KC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SPHK1
• PRDX3
• DENND6A