Seroatlas · Human Serome Atlas

RPS6KL1

Ribosomal protein S6 kinase-like 1

Also known as: MGC11287, RPKL1_HUMAN, RSKL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6S9
Gene
RPS6KL1
Ensembl
ENSG00000198208
Chromosome
14
Canonical length
549 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in chromatin remodeling. Predicted to be located in ribosome. Predicted to be part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

549 residues, UniProt reviewed canonical sequence.

>Q9Y6S9|RPS6KL1
     1  MSLVACECLP SPGLEPEPCS RARSQAHVYL EQIRNRVALG VPDMTKRDYL VDAATQIRLA
    61  LERDVSEDYE AAFNHYQNGV DVLLRGIHVD PNKERREAVK LKITKYLRRA EEIFNCHLQR
   121  PLSSGASPSA GFSSLRLRPI RTLSSAVEQL RGCRVVGVIE KVQLVQDPAT GGTFVVKSLP
   181  RCHMVSRERL TIIPHGVPYM TKLLRYFVSE DSIFLHLEHV QGGTLWSHLL SQAHSRHSGL
   241  SSGSTQERMK AQLNPHLNLL TPARLPSGHA PGQDRIALEP PRTSPNLLLA GEAPSTRPQR
   301  EAEGEPTART STSGSSDLPK APGGHLHLQA RRAGQNSDAG PPRGLTWVPE GAGPVLGGCG
   361  RGMDQSCLSA DGAGRGCGRA TWSVREEQVK QWAAEMLVAL EALHEQGVLC RDLHPGNLLL
   421  DQAGHIRLTY FGQWSEVEPQ CCGEAVDNLY SAPEVGGISE LTEACDWWSF GSLLYELLTG
   481  MALSQSHPSG IQAHTQLQLP EWLSRPAASL LTELLQFEPT RRLGMGEGGV SKLKSHPFFS
   541  TIQWSKLVG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS6KL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 31 nTPM
  • cerebellum: 26 nTPM
  • hippocampal formation: 22 nTPM
  • hypothalamus: 20 nTPM
  • amygdala: 20 nTPM
  • basal ganglia: 20 nTPM

Single-cell type

  • retinal bipolar cells: 84 nCPM
  • rod photoreceptor cells: 66 nCPM
  • cone photoreceptor cells: 58 nCPM
  • retinal amacrine cells: 56 nCPM
  • retinal ganglion cells: 54 nCPM
  • retinal horizontal cells: 42 nCPM

Immune cell

  • plasmacytoid DC: 2.3 nTPM
  • naive CD4 T-cell: 0.8 nTPM
  • naive CD8 T-cell: 0.8 nTPM
  • memory B-cell: 0.7 nTPM
  • gdT-cell: 0.3 nTPM
  • naive B-cell: 0.3 nTPM

Brain region

  • cerebral cortex: 20 nTPM
  • white matter: 16 nTPM
  • hippocampal formation: 16 nTPM
  • basal ganglia: 16 nTPM
  • thalamus: 14 nTPM
  • amygdala: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0
gnomAD missense Z
0.61
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS6KL1 as an antibody target. Whether an autoantibody or antibody against RPS6KL1 could matter depends on whether native RPS6KL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS6KL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS6KL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS6KL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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