Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
IPR015955
Definition
This entry represents a structural motif found at the C-terminal of lactate dehydrogenase ([ec:1.1.1.27])and malate dehydrogenases ([ec:1.1.1.37]), as well as at the C-terminal of family 4 glycoside hydrolases ([ec:3.2.1]). These domains have an unusual fold consisting of segregated α-helical and β-sheet regions, although they contain predominantly anti-parallel β-sheets [[cite:PMID:11276087], [cite:PMID:8117664], [cite:PMID:12588867]]. L-lactate dehydrogenases are metabolic enzymes that catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. O-Glycosyl hydrolases [ec:3.2.1.] are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [[cite:PMID:7624375], [cite:PMID:8535779]]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Glycoside hydrolase family 4 [cazy:GH4] comprises enzymes with several known activities; 6-phospho-beta-glucosidase ([ec:3.2.1.86]); 6-phospho-alpha-glucosidase ([ec:3.2.1.122]); alpha-galactosidase ([ec:3.2.1.22]).
9 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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