Dimeric alpha-beta barrel
IPR011008
Definition
Dimeric α-β barrel domains exhibit an α+β sandwich fold with an antiparallel β-sheet that forms a closed barrel. These domains dimerise through the β-sheet, and in some cases these dimers may assemble into higher oligomers. Domains with this structure are found in proteins from several different families, including bacterial actinorhodin biosynthesis monooxygenase (ActVa-Orf6), which catalyses the oxidation of an aromatic intermediate of the actinorhodin biosynthetic pathway PMID:12514126; bacterial muconalactone isomerase, a decamer composed of five dimers PMID:2926818; and the C-terminal domain of archaeal LprA, a member of the Lrp/AqsnC family of transcription regulators PMID:11230123.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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