Seroatlas · Human Serome Atlas

NIPSNAP3B

Protein NipSnap homolog 3B

Also known as: FLJ11275, NIPSNAP3, NPS3B_HUMAN, SNAP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BS92
Gene: NIPSNAP3B
Ensembl: ENSG00000165028
Chromosome: 9
Canonical length: 247 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

NIPSNAP3B belongs to a family of proteins with putative roles in vesicular trafficking (Buechler et al., 2004 [PubMed 15177564]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>Q9BS92|NIPSNAP3B
     1  MLVLRSGLTK ALASRTLAPQ VCSSFATGPR QYDGTFYEFR TYYLKPSNMN AFMENLKKNI
    61  HLRTSYSELV GFWSVEFGGR TNKVFHIWKY DNFAHRAEVR KALANCKEWQ EQSIIPNLAR
   121  IDKQETEITY LIPWSKLEKP PKEGVYELAV FQMKPGGPAL WGDAFERAIN AHVNLGYTKV
   181  VGVFHTEYGE LNRVHVLWWN ESADSRAAGR HKSHEDPRVV AAVRESVNYL VSQQNMLLIP
   241  ASFSPLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NIPSNAP3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

tongue: 18 nTPM
skeletal muscle: 16 nTPM
heart muscle: 9.2 nTPM
adrenal gland: 7.7 nTPM
adipose tissue: 6.2 nTPM
blood vessel: 5.4 nTPM

Single-cell type

adrenal cortex cells: 119 nCPM
cardiomyocytes: 79 nCPM
adipocytes: 71 nCPM
myonuclei: 58 nCPM
microglia: 43 nCPM
hofbauer cells: 39 nCPM

Immune cell

basophil: 2.8 nTPM
memory B-cell: 0.7 nTPM
eosinophil: 0.6 nTPM
naive B-cell: 0.5 nTPM
non-classical monocyte: 0.4 nTPM
myeloid DC: 0.2 nTPM

Brain region

cerebral cortex: 4.8 nTPM
hypothalamus: 4.6 nTPM
basal ganglia: 4.2 nTPM
choroid plexus: 3.8 nTPM
pons: 3.7 nTPM
amygdala: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0
gnomAD missense Z: 0.28
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitophagy

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NIPSNAP3B as an antibody target. Whether an autoantibody or antibody against NIPSNAP3B could matter depends on whether native NIPSNAP3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NIPSNAP3B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NIPSNAP3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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