Seroatlas · Human Serome Atlas

NIPSNAP3A

Protein NipSnap homolog 3A

Also known as: DKFZp564D177, FLJ13953, HSPC299, MGC14553, NIPSNAP4, NPS3A_HUMAN, TassC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UFN0
Gene: NIPSNAP3A
Ensembl: ENSG00000136783
Chromosome: 9
Canonical length: 247 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

NIPSNAP3A belongs to a family of proteins with putative roles in vesicular transport (Buechler et al., 2004 [PubMed 15177564]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>Q9UFN0|NIPSNAP3A
     1  MLVLRSALTR ALASRTLAPQ MCSSFATGPR QYDGIFYEFR SYYLKPSKMN EFLENFEKNA
    61  HLRTAHSELV GYWSVEFGGR MNTVFHIWKY DNFAHRTEVR KALAKDKEWQ EQFLIPNLAL
   121  IDKQESEITY LVPWCKLEKP PKEGVYELAT FQMKPGGPAL WGDAFKRAVH AHVNLGYTKL
   181  VGVFHTEYGA LNRVHVLWWN ESADSRAAGR HKSHEDPRVV AAVRESVNYL VSQQNMLLIP
   241  TSFSPLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NIPSNAP3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

liver: 48 nTPM
spinal cord: 41 nTPM
bone marrow: 38 nTPM
adrenal gland: 37 nTPM
rectum: 37 nTPM
colon: 36 nTPM

Single-cell type

megakaryocytes: 136 nCPM
hofbauer cells: 134 nCPM
parietal cells: 126 nCPM
oocytes: 120 nCPM
esophageal suprabasal cells: 69 nCPM
hepatocytes: 55 nCPM

Immune cell

myeloid DC: 89 nTPM
intermediate monocyte: 64 nTPM
non-classical monocyte: 57 nTPM
classical monocyte: 52 nTPM
plasmacytoid DC: 45 nTPM
basophil: 43 nTPM

Brain region

white matter: 36 nTPM
medulla oblongata: 31 nTPM
spinal cord: 26 nTPM
hypothalamus: 25 nTPM
midbrain: 24 nTPM
pons: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0
gnomAD missense Z: -0.29
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitophagy

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NIPSNAP3A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NIPSNAP3A as an antibody target. Whether an autoantibody or antibody against NIPSNAP3A could matter depends on whether native NIPSNAP3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NIPSNAP3A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NIPSNAP3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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