PLAC

Definition

The PLAC (protease and lacunin) domain is a six-cysteine region of about 40 residues that is present at or near the C-terminal of various enzymes and matrix proteins, including: mammalian PACE4 (paired basic amino acid cleaving enzyme 4), mammalian PCSK5 (proprotein convertase subtilisin/kexin type 5), mammalian metalloproteinases ADAMTS-2, -3, -10, -12, -14, -16, -17, and -19, and manduca Sexta matrix protein lacunin PMID:11867212. The PLAC domain is often associated with other domains, such as the thrombospondin type I repeat (TSP1) ([interpro:IPR000884]), the Kunitz proteinase inhibitor domain ([interpro:IPR002223]), the Ig-like domain ([interpro:IPR007110]), the WAP domain ([interpro:IPR008197]), the subtilase domain ([interpro:IPR000209]), or the ADAM-type metalloprotease domain ([interpro:IPR001590]).

18 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (18 proteins: gene, accession, name)

• ADAMTS10
• ADAMTS12
• ADAMTS14
• ADAMTS16
• ADAMTS17
• ADAMTS18
• ADAMTS19
• ADAMTS2
• ADAMTS3
• ADAMTS6
• ADAMTS7
• ADAMTSL1
• ADAMTSL2
• ADAMTSL3
• ADAMTSL4
• PAPLN
• PCSK6
• THSD4