FCP1 homology domain

Definition

Yeast FCP1 is an essential protein serine phosphatase ([ec:3.1.3.16]) that dephosphorylates the C-terminal domain (CTD) of RNA polymerase II. FCP1 orthologs are present in all known eukaryote proteomes. The N-terminal domain of FCP1 corresponds to the catalytic unit of the phosphatase and has been refered to as the FCP1 homology domain. The FCP1 homology domain, which is a ~180-residue module, is also found in many other proteins of unknown function. It contains a DxDx(T/V) motif preceded by four hydrophobic residues characteristic of a large family of metal-dependent phosphohydrolases and phosphotransferases. The first aspartate residue is likely to participate in catalysis, whereas the second could have a role in substrate recognition [[cite:PMID:9405607], [cite:PMID:10445027], [cite:PMID:12556522], [cite:PMID:10385623]].

8 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (8 proteins: gene, accession, name)

• CTDNEP1
• CTDP1
• CTDSP1
• CTDSP2
• CTDSPL
• CTDSPL2
• TIMM50
• UBLCP1