CTDSPL

Protein identityUniProt · HPA

UniProt accession

O15194

Gene

CTDSPL

Ensembl

ENSG00000144677

Chromosome

3

Canonical length

276 aa

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of G1/S transition of mitotic cell cycle and negative regulation of protein phosphorylation. Located in extracellular exosome. Biomarker of lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

276 residues, UniProt reviewed canonical sequence.

>O15194|CTDSPL
     1  MDGPAIITQV TNPKEDEGRL PGAGEKASQC NVSLKKQRSR SILSSFFCCF RDYNVEAPPP
    61  SSPSVLPPLV EENGGLQKGD QRQVIPIPSP PAKYLLPEVT VLDYGKKCVV IDLDETLVHS
   121  SFKPISNADF IVPVEIDGTI HQVYVLKRPH VDEFLQRMGQ LFECVLFTAS LAKYADPVAD
   181  LLDRWGVFRA RLFRESCVFH RGNYVKDLSR LGRELSKVII VDNSPASYIF HPENAVPVQS
   241  WFDDMTDTEL LDLIPFFEGL SREDDVYSML HRLCNR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTDSPL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

50 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.96

gnomAD pLI

0

gnomAD missense Z

2.08

DepMap mean gene effect

0.07

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of G1/S transition of mitotic cell cycle

Molecular functions

• metal ion binding
• RNA polymerase II CTD heptapeptide repeat phosphatase activity

Cellular components

• extracellular exosome
• nucleus

Protein domainsUniProt · Pfam · InterPro

• FCP1 homology domain
• Dullard phosphatase domain, eukaryotic
• HAD superfamily
• HAD-like superfamily
• CTD small RNA polymerase II polypeptide A phosphatase-like
• Mitochondrial import inner membrane translocase subunit TIM50
• NLI interacting factor-like phosphatase

KeywordsUniProt

• Hydrolase
• Magnesium
• Metal-binding
• Nucleus
• Protein phosphatase

InteractionsUniProt · HPA

Protein binding partners of CTDSPL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• REST