Seroatlas · Human Serome Atlas

CTDNEP1

CTD nuclear envelope phosphatase 1

Also known as: CNEP1_HUMAN, DULLARD, HSA011916, NET56

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95476
Gene: CTDNEP1
Ensembl: ENSG00000175826
Chromosome: 17
Canonical length: 244 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Lipid droplets

OverviewNCBI Gene

Enables protein serine/threonine phosphatase activity. Involved in several processes, including positive regulation of triglyceride biosynthetic process; protein dephosphorylation; and protein localization to nucleus. Located in endoplasmic reticulum membrane; lipid droplet; and nuclear membrane. Part of Nem1-Spo7 phosphatase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>O95476|CTDNEP1
     1  MMRTQCLLGL RTFVAFAAKL WSFFIYLLRR QIRTVIQYQT VRYDILPLSP VSRNRLAQVK
    61  RKILVLDLDE TLIHSHHDGV LRPTVRPGTP PDFILKVVID KHPVRFFVHK RPHVDFFLEV
   121  VSQWYELVVF TASMEIYGSA VADKLDNSRS ILKRRYYRQH CTLELGSYIK DLSVVHSDLS
   181  SIVILDNSPG AYRSHPDNAI PIKSWFSDPS DTALLNLLPM LDALRFTADV RSVLSRNLHQ
   241  HRLW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTDNEP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 395 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 395 nTPM
tongue: 168 nTPM
heart muscle: 112 nTPM
spleen: 110 nTPM
skin: 109 nTPM
esophagus: 101 nTPM

Single-cell type

oligodendrocytes: 27 nCPM
ependymal cells: 22 nCPM
bergmann glia: 22 nCPM
oligodendrocyte progenitor cells: 21 nCPM
microglia: 20 nCPM
brain excitatory neurons: 19 nCPM

Immune cell

eosinophil: 10 nTPM
plasmacytoid DC: 9.1 nTPM
neutrophil: 7.9 nTPM
memory B-cell: 7.1 nTPM
naive B-cell: 6.7 nTPM
intermediate monocyte: 6.1 nTPM

Brain region

thalamus: 56 nTPM
medulla oblongata: 55 nTPM
amygdala: 49 nTPM
midbrain: 49 nTPM
cerebral cortex: 48 nTPM
basal ganglia: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 0.97
gnomAD missense Z: 2.54
DepMap mean gene effect: -0.45
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CTDNEP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CNEP1R1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTDNEP1 as an antibody target. Whether an autoantibody or antibody against CTDNEP1 could matter depends on whether native CTDNEP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTDNEP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTDNEP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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