CTDSP1

Protein identityUniProt · HPA

UniProt accession

Q9GZU7

Gene

CTDSP1

Ensembl

ENSG00000144579

Chromosome

2

Canonical length

261 aa

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>Q9GZU7|CTDSP1
     1  MDSSAVITQI SKEEARGPLR GKGDQKSAAS QKPRSRGILH SLFCCVCRDD GEALPAHSGA
    61  PLLVEENGAI PKQTPVQYLL PEAKAQDSDK ICVVIDLDET LVHSSFKPVN NADFIIPVEI
   121  DGVVHQVYVL KRPHVDEFLQ RMGELFECVL FTASLAKYAD PVADLLDKWG AFRARLFRES
   181  CVFHRGNYVK DLSRLGRDLR RVLILDNSPA SYVFHPDNAV PVASWFDNMS DTELHDLLPF
   241  FEQLSRVDDV YSVLRQPRPG S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTDSP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

121 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.2

gnomAD pLI

0.99

gnomAD missense Z

1.15

DepMap mean gene effect

0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of G1/S transition of mitotic cell cycle
• negative regulation of neurogenesis
• negative regulation of neuron differentiation
• protein dephosphorylation
• regulation of transcription by RNA polymerase II

Molecular functions

• metal ion binding
• RNA polymerase II CTD heptapeptide repeat phosphatase activity

Cellular components

• extracellular exosome
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• FCP1 homology domain
• Dullard phosphatase domain, eukaryotic
• HAD superfamily
• HAD-like superfamily
• CTD small RNA polymerase II polypeptide A phosphatase-like
• Mitochondrial import inner membrane translocase subunit TIM50
• NLI interacting factor-like phosphatase

KeywordsUniProt

• Acetylation
• Hydrolase
• Magnesium
• Metal-binding
• Nucleus
• Protein phosphatase

InteractionsUniProt · HPA

Protein binding partners of CTDSP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GTF2F1
• REST
• CDCA3
• MBP
• PNMA1