Seroatlas · Human Serome Atlas

CTDSPL2

CTD small phosphatase-like protein 2

Also known as: CTSL2_HUMAN, FLJ10523, HSPC129

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q05D32
Gene
CTDSPL2
Ensembl
ENSG00000137770
Chromosome
15
Canonical length
466 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of BMP signaling pathway; positive regulation of protein export from nucleus; and protein dephosphorylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

466 residues, UniProt reviewed canonical sequence.

>Q05D32|CTDSPL2
     1  MRLRTRKASQ QSNQIQTQRT ARAKRKYSEV DDSLPSGGEK PSKNETGLLS SIKKFIKGST
    61  PKEERENPSK RSRIERDIDN NLITSTPRAG EKPNKQISRV RRKSQVNGEA GSYEMTNQHV
   121  KQNGKLEDNP SSGSPPRTTL LGTIFSPVFN FFSPANKNGT SGSDSPGQAV EAEEIVKQLD
   181  MEQVDEITTS TTTSTNGAAY SNQAVQVRPS LNNGLEEAEE TVNRDIPPLT APVTPDSGYS
   241  SAHAEATYEE DWEVFDPYYF IKHVPPLTEE QLNRKPALPL KTRSTPEFSL VLDLDETLVH
   301  CSLNELEDAA LTFPVLFQDV IYQVYVRLRP FFREFLERMS QMYEIILFTA SKKVYADKLL
   361  NILDPKKQLV RHRLFREHCV CVQGNYIKDL NILGRDLSKT IIIDNSPQAF AYQLSNGIPI
   421  ESWFMDKNDN ELLKLIPFLE KLVELNEDVR PHIRDRFRLH DLLPPD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTDSPL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 24 nTPM
  • testis: 20 nTPM
  • bone marrow: 19 nTPM
  • lymph node: 18 nTPM
  • tonsil: 18 nTPM
  • ovary: 17 nTPM

Single-cell type

  • late spermatids: 234 nCPM
  • early spermatids: 219 nCPM
  • sertoli cells: 162 nCPM
  • myonuclei: 157 nCPM
  • fibro-adipogenic progenitors: 155 nCPM
  • monocyte progenitors: 139 nCPM

Immune cell

  • NK-cell: 16 nTPM
  • T-reg: 15 nTPM
  • myeloid DC: 14 nTPM
  • naive CD8 T-cell: 12 nTPM
  • intermediate monocyte: 11 nTPM
  • classical monocyte: 11 nTPM

Brain region

  • cerebellum: 36 nTPM
  • white matter: 21 nTPM
  • cerebral cortex: 20 nTPM
  • hypothalamus: 18 nTPM
  • basal ganglia: 17 nTPM
  • medulla oblongata: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.17
gnomAD pLI
1
gnomAD missense Z
2.2
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CTDSPL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTDSPL2 as an antibody target. Whether an autoantibody or antibody against CTDSPL2 could matter depends on whether native CTDSPL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTDSPL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTDSPL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CTDSPL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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