Seroatlas · Human Serome Atlas

CTDSP2

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

Also known as: CTDS2_HUMAN, OS4, PSR2, SCP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14595
Gene: CTDSP2
Ensembl: ENSG00000175215
Chromosome: 12
Canonical length: 271 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Involved in protein dephosphorylation. Predicted to be located in nucleoplasm. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>O14595|CTDSP2
     1  MEHGSIITQA RREDALVLTK QGLVSKSSPK KPRGRNIFKA LFCCFRAQHV GQSSSSTELA
    61  AYKEEANTIA KSDLLQCLQY QFYQIPGTCL LPEVTEEDQG RICVVIDLDE TLVHSSFKPI
   121  NNADFIVPIE IEGTTHQVYV LKRPYVDEFL RRMGELFECV LFTASLAKYA DPVTDLLDRC
   181  GVFRARLFRE SCVFHQGCYV KDLSRLGRDL RKTLILDNSP ASYIFHPENA VPVQSWFDDM
   241  ADTELLNLIP IFEELSGAED VYTSLGQLRA P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTDSP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 115 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 115 nTPM
pancreas: 113 nTPM
lung: 107 nTPM
colon: 103 nTPM
salivary gland: 103 nTPM
blood vessel: 100 nTPM

Single-cell type

late spermatids: 255 nCPM
platelets: 215 nCPM
colonocytes: 112 nCPM
neutrophils: 108 nCPM
kupffer cells: 106 nCPM
cholangiocytes: 87 nCPM

Immune cell

neutrophil: 17 nTPM
eosinophil: 15 nTPM
basophil: 13 nTPM
naive CD4 T-cell: 9.8 nTPM
classical monocyte: 9.1 nTPM
memory CD4 T-cell: 8.7 nTPM

Brain region

medulla oblongata: 152 nTPM
white matter: 132 nTPM
midbrain: 129 nTPM
basal ganglia: 126 nTPM
cerebellum: 125 nTPM
pons: 120 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0.11
gnomAD missense Z: 1.51
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CTDSP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTDSP2 as an antibody target. Whether an autoantibody or antibody against CTDSP2 could matter depends on whether native CTDSP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTDSP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTDSP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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