Seroatlas · Human Serome Atlas

NSUN5P2

Putative methyltransferase NSUN5C

Also known as: NSN5C_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q63ZY6
Gene: NSUN5P2
Canonical length: 315 aa

OverviewNCBI Gene

No narrative summary is available for NSUN5P2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q63ZY6|NSUN5P2
     1  MPELLVFPAQ TDLHEHPLYR AGHLILQDRA SCLPAMLLDP RQAPMSWMPV PPQAIKTSHL
    61  AALLKNQGKI FAFDLDARRL ASMATLLAWA GVSCCELAEE DFLAVSPLDP RYREVHYVLL
   121  DPSCSGSGMP SRQLEEPGAG TPSPVRLHAL AGFQQRALCH ALTFPSLQRL VYSMCSLCQE
   181  ENEDMVQDAL QQNPGAFRLA PALPARPHRG LSTFPGAEHC LRASPKTTLS GGFFVAVIER
   241  VEMPTSASQA KASAPERTPS PAPKRKKRAK SCSRCLHTAL HIAEAPGSLL PGGKGRCLSS
   301  PWKTLGPHRR QQFAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NSUN5P2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

RNA methylation

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NSUN5P2 as an antibody target. Whether an autoantibody or antibody against NSUN5P2 could matter depends on whether native NSUN5P2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NSUN5P2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NSUN5P2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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