Seroatlas · Human Serome Atlas

NSUN6

tRNA (cytosine(72)-C(5))-methyltransferase NSUN6

Also known as: ARL5B-AS1, FLJ23743, NOPD1, NSUN6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TEA1
Gene
NSUN6
Ensembl
ENSG00000241058
Chromosome
10
Canonical length
469 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

Enables tRNA (cytidine-5-)-methyltransferase activity and tRNA binding activity. Involved in tRNA C5-cytosine methylation. Located in cytoplasm. Implicated in autosomal recessive intellectual developmental disorder 82. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

469 residues, UniProt reviewed canonical sequence.

>Q8TEA1|NSUN6
     1  MSIFPKISLR PEVENYLKEG FMNKEIVTAL GKQEAERKFE TLLKHLSHPP SFTTVRVNTH
    61  LASVQHVKNL LLDELQKQFN GLSVPILQHP DLQDVLLIPV IGPRKNIKKQ QCEAIVGAQC
   121  GNAVLRGAHV YAPGIVSASQ FMKAGDVISV YSDIKGKCKK GAKEFDGTKV FLGNGISELS
   181  RKEIFSGLPE LKGMGIRMTE PVYLSPSFDS VLPRYLFLQN LPSALVSHVL NPQPGEKILD
   241  LCAAPGGKTT HIAALMHDQG EVIALDKIFN KVEKIKQNAL LLGLNSIRAF CFDGTKAVKL
   301  DMVEDTEGEP PFLPESFDRI LLDAPCSGMG QRPNMACTWS VKEVASYQPL QRKLFTAAVQ
   361  LLKPEGVLVY STCTITLAEN EEQVAWALTK FPCLQLQPQE PQIGGEGMRG AGLSCEQLKQ
   421  LQRFDPSAVP LPDTDMDSLR EARREDMLRL ANKDSIGFFI AKFVKCKST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NSUN6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
57 nTPM

Expression across tissuesHPA

Tissue

  • liver: 57 nTPM
  • testis: 17 nTPM
  • pituitary gland: 17 nTPM
  • spinal cord: 13 nTPM
  • cerebellum: 13 nTPM
  • ovary: 13 nTPM

Single-cell type

  • hepatocytes: 367 nCPM
  • epididymal basal cells: 240 nCPM
  • granulosa cells: 234 nCPM
  • urothelial cells: 198 nCPM
  • sertoli cells: 183 nCPM
  • enterocytes: 164 nCPM

Immune cell

  • T-reg: 11 nTPM
  • non-classical monocyte: 8.3 nTPM
  • memory B-cell: 8.1 nTPM
  • naive CD4 T-cell: 7.8 nTPM
  • MAIT T-cell: 7 nTPM
  • naive CD8 T-cell: 6.7 nTPM

Brain region

  • white matter: 24 nTPM
  • cerebellum: 22 nTPM
  • cerebral cortex: 21 nTPM
  • midbrain: 20 nTPM
  • medulla oblongata: 19 nTPM
  • basal ganglia: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NSUN6.

Disease | AllUniProt

Conditions NSUN6 is implicated in, by any mechanism.

  • Intellectual developmental disorder, autosomal recessive 82 (MRT82) MIM:620779

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 108 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Intellectual developmental disorder, autosomal recessive 82

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.48
gnomAD pLI
0
gnomAD missense Z
-1.33
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NSUN6 as an antibody target. Whether an autoantibody or antibody against NSUN6 could matter depends on whether native NSUN6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NSUN6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NSUN6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NSUN6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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