Seroatlas · Human Serome Atlas

NSUN7

Putative methyltransferase NSUN7

Also known as: FLJ14001, NSUN7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NE18
Gene
NSUN7
Ensembl
ENSG00000179299
Chromosome
4
Canonical length
718 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Predicted to enable RNA binding activity and methyltransferase activity. Predicted to be involved in RNA methylation and RNA processing. Predicted to act upstream of or within flagellated sperm motility and sperm mitochondrion organization. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

718 residues, UniProt reviewed canonical sequence.

>Q8NE18|NSUN7
     1  MLNSTGELEF SNEEDPEIIS QLTSLPLSGG KSSAGVPEKT GYPDSVYVMA ANIFQGIRIE
    61  KSAQKVLIKY GNEPLRSLSE SEDQSFQRLS YELAFSALKY QDILETILID SCIFPSTTIP
   121  DHLSSLIIVM LYDFQDRKFQ TRVLSDNEEP ISEVQEVENL LNSFKIKLAA ALARCRIKHD
   181  ALSIYHILPE TVRKQELRAS TLPLYAWINT CKISPEEVYN NLKRRGYNKV KSVLHIDDKV
   241  FAVDQHCYDV LIFPSHLKND LINIDLFKDY KLIFQDKSRS LAVHSVKALL NMDDDVLMVN
   301  TGSWYTVSHM SILTNNNTSK VFVCGVQSQA KDPDLKTLFT KIGCKNIEIL HEKFINIESK
   361  DHRLQKVKVI LLLPRCSGLG VSNPVEFILN EHEDTEFLKD HSQGGISVDK LHVLAQQQYE
   421  QLTHAMKFTK AQAVVYCTCS VFPEENEAVV KKALEFQDLG NKGQPYRLSP PVLPLCSLKE
   481  IQLSTDKFFR MEPSEITNGC FLSILTRERD PSETVSVNDV LARAAAKGLL DGIELGKSSK
   541  REKKKKKSKT SLTKGATTDN GIQMKIAEFL NRETKASANL SETVTKPPLP QKNTAQVGAS
   601  SQTRKPNKLA PHPAVPAFVK NTCPSRPRER QTHFLRPRPE DRMVALKPIK IVLPPVFMPF
   661  SSPQGIRSRM PTQHLYCRWV APKALVPTCL PTHSLSRKEE KPKDDTPSSL LRPPRRWL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NSUN7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • testis: 15 nTPM
  • choroid plexus: 9.4 nTPM
  • fallopian tube: 6.4 nTPM
  • pancreas: 6.1 nTPM
  • blood vessel: 4.6 nTPM
  • kidney: 4.5 nTPM

Single-cell type

  • respiratory ciliated cells: 366 nCPM
  • neutrophils: 275 nCPM
  • late spermatids: 164 nCPM
  • fallopian tube ciliated cells: 137 nCPM
  • ependymal cells: 132 nCPM
  • renal collecting duct intercalated cells: 124 nCPM

Immune cell

  • neutrophil: 2.7 nTPM
  • naive B-cell: 0.4 nTPM
  • memory B-cell: 0.3 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • choroid plexus: 16 nTPM
  • midbrain: 5.4 nTPM
  • hypothalamus: 4.4 nTPM
  • medulla oblongata: 4.3 nTPM
  • spinal cord: 3 nTPM
  • pons: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.79
gnomAD pLI
0
gnomAD missense Z
0.48
DepMap mean gene effect
-0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NSUN7 as an antibody target. Whether an autoantibody or antibody against NSUN7 could matter depends on whether native NSUN7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NSUN7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NSUN7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NSUN7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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