Seroatlas · Human Serome Atlas

ZNF592

Zinc finger protein 592

Also known as: CAMOS, KIAA0211, SCAR5, ZN592_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92610
Gene: ZNF592
Ensembl: ENSG00000166716
Chromosome: 15
Canonical length: 1267 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene is thought to play a role in a complex developmental pathway and the regulation of genes involved in cerebellar development. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

1267 residues, UniProt reviewed canonical sequence.

>Q92610|ZNF592
     1  MGDMKTPDFD DLLAAFDIPD PTSLDAKEAI QTPSEENESP LKPPGICMDE SVSLSHSGSA
    61  PDVPAVSVIV KNTSRQESFE AEKDHITPSL LHNGFRGSDL PPDPHNCGKF DSTFMNGDSA
   121  RSFPGKLEPP KSEPLPTFNQ FSPISSPEPE DPIKDNGFGI KPKHSDSYFP PPLGCGAVGG
   181  PVLEALAKFP VPELHMFDHF CKKEPKPEPL PLGSQQEHEQ SGQNTVEPHK DPDATRFFGE
   241  ALEFNSHPSN SIGESKGLAR ELGTCSSVPP RQRLKPAHSK LSSCVAALVA LQAKRVASVT
   301  KEDQPGHTKD LSGPTKESSK GSPKMPKSPK SPRSPLEATR KSIKPSDSPR SICSDSSSKG
   361  SPSVAASSPP AIPKVRIKTI KTSSGEIKRT VTRILPDPDD PSKSPVGSPL GSAIAEAPSE
   421  MPGDEVPVEE HFPEAGTNSG SPQGARKGDE SMTKASDSSS PSCSSGPRVP KGAAPGSQTG
   481  KKQQSTALQA STLAPANLLP KAVHLANLNL VPHSVAASVT AKSSVQRRSQ PQLTQMSVPL
   541  VHQVKKAAPL IVEVFNKVLH SSNPVPLYAP NLSPPADSRI HVPASGYCCL ECGDAFALEK
   601  SLSQHYGRRS VHIEVLCTLC SKTLLFFNKC SLLRHARDHK SKGLVMQCSQ LLVKPISADQ
   661  MFVSAPVNST APAAPAPSSS PKHGLTSGSA SPPPPALPLY PDPVRLIRYS IKCLECHKQM
   721  RDYMVLAAHF QRTTEETEGL TCQVCQMLLP NQCSFCAHQR IHAHKSPYCC PECGVLCRSA
   781  YFQTHVKENC LHYARKVGYR CIHCGVVHLT LALLKSHIQE RHCQVFHKCA FCPMAFKTAS
   841  STADHSATQH PTQPHRPSQL IYKCSCEMVF NKKRHIQQHF YQNVSKTQVG VFKCPECPLL
   901  FVQKPELMQH VKSTHGVPRN VDELSSLQSS ADTSSSRPGS RVPTEPPATS VAARSSSLPS
   961  GRWGRPEAHR RVEARPRLRN TGWTCQECQE WVPDRESYVS HMKKSHGRTL KRYPCRQCEQ
  1021  SFHTPNSLRK HIRNNHDTVK KFYTCGYCTE DSPSFPRPSL LESHISLMHG IRNPDLSQTS
  1081  KVKPPGGHSP QVNHLKRPVS GVGDAPGTSN GATVSSTKRH KSLFQCAKCS FATDSGLEFQ
  1141  SHIPQHQVDS STAQCLLCGL CYTSASSLSR HLFIVHKVRD QEEEEEEEAA AAEMAVEVAE
  1201  PEEGSGEEVP METRENGLEE CAGEPLSADP EARRLLGPAP EDDGGHNDHS QPQASQDQDS
  1261  HTLSPQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF592 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 18 nTPM
tongue: 14 nTPM
blood vessel: 12 nTPM
ovary: 11 nTPM
spleen: 11 nTPM
thymus: 11 nTPM

Single-cell type

myonuclei: 157 nCPM
neutrophils: 126 nCPM
adipocytes: 118 nCPM
neutrophil progenitors: 99 nCPM
microglia: 92 nCPM
cardiomyocytes: 78 nCPM

Immune cell

neutrophil: 2.6 nTPM
memory B-cell: 1.5 nTPM
intermediate monocyte: 1.4 nTPM
naive B-cell: 1.4 nTPM
myeloid DC: 1.3 nTPM
non-classical monocyte: 1.3 nTPM

Brain region

medulla oblongata: 24 nTPM
thalamus: 21 nTPM
cerebellum: 21 nTPM
midbrain: 21 nTPM
white matter: 21 nTPM
pons: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.13
gnomAD pLI: 1
gnomAD missense Z: 0.8
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of insulin receptor signaling pathway

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF592 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZMYND8

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF592 as an antibody target. Whether an autoantibody or antibody against ZNF592 could matter depends on whether native ZNF592 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF592 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF592 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...