Seroatlas · Human Serome Atlas

ZNF687

Zinc finger protein 687

Also known as: KIAA1441, ZN687_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N1G0
Gene: ZNF687
Ensembl: ENSG00000143373
Chromosome: 1
Canonical length: 1237 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes C2H2 zinc finger protein. The encoded protein may play a role in bone differentiation and development. Mutations in this gene are the cause of Paget disease of bone-6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

1237 residues, UniProt reviewed canonical sequence.

>Q8N1G0|ZNF687
     1  MGDMKTPDFD DLLAAFDIPD IDANEAIHSG PEENEGPGGP GKPEPGVGSE SEDTAAASAG
    61  DGPGVPAQAS DHGLPPPDIS VVSVIVKNTV CPEQSEALAG GSAGDGAQAA GVTKEGPVGP
   121  HRMQNGFGSP EPSLPGTPHS PAPPSGGTWK EKGMEGKTPL DLFAHFGPEP GDHSDPLPPS
   181  APSPTREGAL TPPPFPSSFE LAQENGPGMQ PPVSSPPLGA LKQESCSPHH PQVLAQQGSG
   241  SSPKATDIPA SASPPPVAGV PFFKQSPGHQ SPLASPKVPV CQPLKEEDDD EGPVDKSSPG
   301  SPQSPSSGAE AADEDSNDSP ASSSSRPLKV RIKTIKTSCG NITRTVTQVP SDPDPPAPLA
   361  EGAFLAEASL LKLSPATPTS EGPKVVSVQL GDGTRLKGTV LPVATIQNAS TAMLMAASVA
   421  RKAVVLPGGT ATSPKMIAKN VLGLVPQALP KADGRAGLGT GGQKVNGASV VMVQPSKTAT
   481  GPSTGGGTVI SRTQSSLVEA FNKILNSKNL LPAYRPNLSP PAEAGLALPP TGYRCLECGD
   541  AFSLEKSLAR HYDRRSMRIE VTCNHCARRL VFFNKCSLLL HAREHKDKGL VMQCSHLVMR
   601  PVALDQMVGQ PDITPLLPVA VPPVSGPLAL PALGKGEGAI TSSAITTVAA EAPVLPLSTE
   661  PPAAPATSAY TCFRCLECKE QCRDKAGMAA HFQQLGPPAP GATSNVCPTC PMMLPNRCSF
   721  SAHQRMHKNR PPHVCPECGG NFLQANFQTH LREACLHVSR RVGYRCPSCS VVFGGVNSIK
   781  SHIQTSHCEV FHKCPICPMA FKSGPSAHAH LYSQHPSFQT QQAKLIYKCA MCDTVFTHKP
   841  LLSSHFDQHL LPQRVSVFKC PSCPLLFAQK RTMLEHLKNT HQSGRLEETA GKGAGGALLT
   901  PKTEPEELAV SQGGAAPATE ESSSSSEEEE VPSSPEPPRP AKRPRRELGS KGLKGGGGGP
   961  GGWTCGLCHS WFPERDEYVA HMKKEHGKSV KKFPCRLCER SFCSAPSLRR HVRVNHEGIK
  1021  RVYPCRYCTE GKRTFSSRLI LEKHVQVRHG LQLGAQSPGR GTTLARGSSA RAQGPGRKRR
  1081  QSSDSCSEEP DSTTPPAKSP RGGPGSGGHG PLRYRSSSST EQSLMMGLRV EDGAQQCLDC
  1141  GLCFASPGSL SRHRFISHKK RRGVGKASAL GLGDGEEEAP PSRSDPDGGD SPLPASGGPL
  1201  TCKVCGKSCD SPLNLKTHFR THGMAFIRAR QGAVGDN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF687 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 29 nTPM
pancreas: 15 nTPM
testis: 14 nTPM
spleen: 14 nTPM
parathyroid gland: 13 nTPM
pituitary gland: 13 nTPM

Single-cell type

neutrophils: 29 nCPM
epididymal clear cells: 16 nCPM
enterocytes: 16 nCPM
esophageal apical cells: 14 nCPM
cholangiocytes: 11 nCPM
adrenal medulla cells: 11 nCPM

Immune cell

eosinophil: 14 nTPM
neutrophil: 8.9 nTPM
non-classical monocyte: 4.5 nTPM
intermediate monocyte: 2.3 nTPM
classical monocyte: 1.7 nTPM
total PBMC: 1.1 nTPM

Brain region

cerebellum: 28 nTPM
medulla oblongata: 24 nTPM
white matter: 23 nTPM
midbrain: 22 nTPM
thalamus: 22 nTPM
pons: 22 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF687.

Disease | AllUniProt

Conditions ZNF687 is implicated in, by any mechanism.

Paget disease of bone 6 (PDB6) MIM:616833

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 602 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Paget disease of bone 6

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 1.81
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF687 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF687 as an antibody target. Whether an autoantibody or antibody against ZNF687 could matter depends on whether native ZNF687 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF687 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF687 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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