LMO1

Protein identityUniProt · HPA

UniProt accession

P25800

Gene

LMO1

Ensembl

ENSG00000166407

Chromosome

11

Canonical length

156 aa

Protein class

Cancer-related genes, Disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

156 residues, UniProt reviewed canonical sequence.

>P25800|LMO1
     1  MMVLDKEDGV PMLSVQPKGK QKGCAGCNRK IKDRYLLKAL DKYWHEDCLK CACCDCRLGE
    61  VGSTLYTKAN LILCRRDYLR LFGTTGNCAA CSKLIPAFEM VMRARDNVYH LDCFACQLCN
   121  QRFCVGDKFF LKNNMILCQM DYEEGQLNGT FESQVQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LMO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

28 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.63

gnomAD pLI

0.64

gnomAD missense Z

0.38

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of transcription by RNA polymerase II
• positive regulation of transcription by RNA polymerase II
• regulation of T cell homeostatic proliferation

Molecular functions

• DNA-binding transcription factor binding
• metal ion binding
• transcription coactivator activity

Cellular components

• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Zinc finger, LIM-type
• LMO/RBTN Transcription Factors
• LIM domain

KeywordsUniProt

• Chromosomal rearrangement
• LIM domain
• Metal-binding
• Nucleus
• Proto-oncogene
• Repeat
• Zinc

InteractionsUniProt · HPA

Protein binding partners of LMO1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LDB1
• ZBTB43