Seroatlas · Human Serome Atlas

LMO3

LIM domain only protein 3

Also known as: DAT1, LMO3_HUMAN, RBTNL2, Rhom-3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAP4
Gene: LMO3
Ensembl: ENSG00000048540
Chromosome: 12
Canonical length: 145 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. This gene is predominantly expressed in the brain. Related family members, LMO1 and LMO2 on chromosome 11, have been reported to be involved in chromosomal translocations in T-cell leukemia. Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

145 residues, UniProt reviewed canonical sequence.

>Q8TAP4|LMO3
     1  MLSVQPDTKP KGCAGCNRKI KDRYLLKALD KYWHEDCLKC ACCDCRLGEV GSTLYTKANL
    61  ILCRRDYLRL FGVTGNCAAC SKLIPAFEMV MRAKDNVYHL DCFACQLCNQ RFCVGDKFFL
   121  KNNMILCQTD YEEGLMKEGY APQVR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LMO3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 110 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 110 nTPM
amygdala: 97 nTPM
cerebral cortex: 91 nTPM
colon: 67 nTPM
hippocampal formation: 54 nTPM
urinary bladder: 42 nTPM

Single-cell type

alveolar cells type 1: 645 nCPM
alveolar cells type 2: 546 nCPM
transitional alveolar cells: 473 nCPM
medullary thymic epithelial cells: 413 nCPM
astrocytes: 402 nCPM
adipocytes: 388 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 141 nTPM
cerebral cortex: 139 nTPM
hypothalamus: 95 nTPM
amygdala: 90 nTPM
hippocampal formation: 89 nTPM
midbrain: 88 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0.71
gnomAD missense Z: 2.01
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LMO3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LMO3 as an antibody target. Whether an autoantibody or antibody against LMO3 could matter depends on whether native LMO3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LMO3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LMO3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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