Seroatlas · Human Serome Atlas

GATA3

Trans-acting T-cell-specific transcription factor GATA-3

Also known as: GATA3_HUMAN, HDR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P23771
Gene
GATA3
Ensembl
ENSG00000107485
Chromosome
10
Canonical length
443 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]

Canonical amino-acid sequenceUniProt

443 residues, UniProt reviewed canonical sequence.

>P23771|GATA3
     1  MEVTADQPRW VSHHHPAVLN GQHPDTHHPG LSHSYMDAAQ YPLPEEVDVL FNIDGQGNHV
    61  PPYYGNSVRA TVQRYPPTHH GSQVCRPPLL HGSLPWLDGG KALGSHHTAS PWNLSPFSKT
   121  SIHHGSPGPL SVYPPASSSS LSGGHASPHL FTFPPTPPKD VSPDPSLSTP GSAGSARQDE
   181  KECLKYQVPL PDSMKLESSH SRGSMTALGG ASSSTHHPIT TYPPYVPEYS SGLFPPSSLL
   241  GGSPTGFGCK SRPKARSSTG RECVNCGATS TPLWRRDGTG HYLCNACGLY HKMNGQNRPL
   301  IKPKRRLSAA RRAGTSCANC QTTTTTLWRR NANGDPVCNA CGLYYKLHNI NRPLTMKKEG
   361  IQTRNRKMSS KSKKCKKVHD SLEDFPKNSS FNPAALSRHM SSLSHISPFS HSSHMLTTPT
   421  PMHPPSSLSF GPHHPSSMVT AMG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GATA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
169 nTPM

Expression across tissuesHPA

Tissue

  • skin: 169 nTPM
  • parathyroid gland: 112 nTPM
  • urinary bladder: 35 nTPM
  • breast: 34 nTPM
  • placenta: 32 nTPM
  • kidney: 27 nTPM

Single-cell type

  • syncytiotrophoblasts: 1,534 nCPM
  • extravillous trophoblasts: 1,181 nCPM
  • migrating cytotrophoblasts: 831 nCPM
  • breast hormone-responsive cells: 488 nCPM
  • urothelial cells: 465 nCPM
  • renal collecting duct principal cells: 459 nCPM

Immune cell

  • T-reg: 51 nTPM
  • memory CD4 T-cell: 42 nTPM
  • NK-cell: 40 nTPM
  • memory CD8 T-cell: 34 nTPM
  • MAIT T-cell: 33 nTPM
  • gdT-cell: 25 nTPM

Brain region

  • midbrain: 66 nTPM
  • pons: 31 nTPM
  • thalamus: 11 nTPM
  • medulla oblongata: 9.6 nTPM
  • amygdala: 2.5 nTPM
  • choroid plexus: 2.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GATA3.

Disease | AllUniProt

Conditions GATA3 is implicated in, by any mechanism.

  • Hypoparathyroidism, sensorineural deafness, and renal disease (HDR) MIM:146255

Disease | GeneticClinVar

110 pathogenic / likely-pathogenic of 520 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.9
gnomAD missense Z
1.91
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GATA3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GATA3 as an antibody target. Whether an autoantibody or antibody against GATA3 could matter depends on whether native GATA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GATA3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GATA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GATA3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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