Seroatlas · Human Serome Atlas

ZNF71

Endothelial zinc finger protein induced by tumor necrosis factor alpha

Also known as: Cos26, EZFIT, ZNF71_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NQZ8
Gene
ZNF71
Ensembl
ENSG00000197951
Chromosome
19
Canonical length
489 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

489 residues, UniProt reviewed canonical sequence.

>Q9NQZ8|ZNF71
     1  MKELDPKNDI SEDKLSVVGE ATGGPTRNGA RGPGSEGVWE PGSWPERPRG DAGAEWEPLG
    61  IPQGNKLLGG SVPACHELKA FANQGCVLVP PRLDDPTEKG ACPPVRRGKN FSSTSDLSKP
   121  PMPCEEKKTY DCSECGKAFS RSSSLIKHQR IHTGEKPFEC DTCGKHFIER SSLTIHQRVH
   181  TGEKPYACGD CGKAFSQRMN LTVHQRTHTG EKPYVCDVCG KAFRKTSSLT QHERIHTGEK
   241  PYACGDCGKA FSQNMHLIVH QRTHTGEKPY VCPECGRAFS QNMHLTEHQR THTGEKPYAC
   301  KECGKAFNKS SSLTLHQRNH TGEKPYVCGE CGKAFSQSSY LIQHQRFHIG VKPFECSECG
   361  KAFSKNSSLT QHQRIHTGEK PYECYICKKH FTGRSSLIVH QIVHTGEKPY VCGECGKAFS
   421  QSAYLIEHQR IHTGEKPYRC GQCGKSFIKN SSLTVHQRIH TGEKPYRCGE CGKTFSRNTN
   481  LTRHLRIHT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF71 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
4.2 nTPM

Expression across tissuesHPA

Tissue

  • endometrium: 4.2 nTPM
  • heart muscle: 4 nTPM
  • colon: 3.7 nTPM
  • blood vessel: 3.6 nTPM
  • cerebellum: 3.5 nTPM
  • cervix: 3.5 nTPM

Single-cell type

  • podocytes: 9 nCPM
  • distal convoluted tubule cells: 6 nCPM
  • proximal tubule cells: 5.7 nCPM
  • renal connecting tubule cells: 5.4 nCPM
  • renal collecting duct intercalated cells: 5.3 nCPM
  • loop of henle epithelial cells: 4.9 nCPM

Immune cell

  • NK-cell: 6.1 nTPM
  • MAIT T-cell: 4.5 nTPM
  • gdT-cell: 4.3 nTPM
  • T-reg: 3.8 nTPM
  • memory CD8 T-cell: 3.6 nTPM
  • naive B-cell: 3.6 nTPM

Brain region

  • hippocampal formation: 17 nTPM
  • cerebral cortex: 17 nTPM
  • amygdala: 13 nTPM
  • basal ganglia: 13 nTPM
  • midbrain: 13 nTPM
  • cerebellum: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
0.69
DepMap mean gene effect
0.2
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF71 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF71 as an antibody target. Whether an autoantibody or antibody against ZNF71 could matter depends on whether native ZNF71 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF71 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF71 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF71. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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