Seroatlas · Human Serome Atlas

YTHDF2

YTH domain-containing family protein 2

Also known as: CAHL, HGRG8, NY-REN-2, YTHD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5A9
Gene
YTHDF2
Ensembl
ENSG00000198492
Chromosome
1
Canonical length
579 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol,Cytoplasmic bodies

OverviewNCBI Gene

This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

579 residues, UniProt reviewed canonical sequence.

>Q9Y5A9|YTHDF2
     1  MSASSLLEQR PKGQGNKVQN GSVHQKDGLN DDDFEPYLSP QARPNNAYTA MSDSYLPSYY
    61  SPSIGFSYSL GEAAWSTGGD TAMPYLTSYG QLSNGEPHFL PDAMFGQPGA LGSTPFLGQH
   121  GFNFFPSGID FSAWGNNSSQ GQSTQSSGYS SNYAYAPSSL GGAMIDGQSA FANETLNKAP
   181  GMNTIDQGMA ALKLGSTEVA SNVPKVVGSA VGSGSITSNI VASNSLPPAT IAPPKPASWA
   241  DIASKPAKQQ PKLKTKNGIA GSSLPPPPIK HNMDIGTWDN KGPVAKAPSQ ALVQNIGQPT
   301  QGSPQPVGQQ ANNSPPVAQA SVGQQTQPLP PPPPQPAQLS VQQQAAQPTR WVAPRNRGSG
   361  FGHNGVDGNG VGQSQAGSGS TPSEPHPVLE KLRSINNYNP KDFDWNLKHG RVFIIKSYSE
   421  DDIHRSIKYN IWCSTEHGNK RLDAAYRSMN GKGPVYLLFS VNGSGHFCGV AEMKSAVDYN
   481  TCAGVWSQDK WKGRFDVRWI FVKDVPNSQL RHIRLENNEN KPVTNSRDTQ EVPLEKAKQV
   541  LKIIASYKHT TSIFDDFSHY EKRQEEEESV KKERQGRGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YTHDF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
60 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 60 nTPM
  • skeletal muscle: 43 nTPM
  • epididymis: 41 nTPM
  • thymus: 41 nTPM
  • tonsil: 41 nTPM
  • skin: 41 nTPM

Single-cell type

  • syncytiotrophoblasts: 317 nCPM
  • esophageal apical cells: 218 nCPM
  • migrating cytotrophoblasts: 194 nCPM
  • cytotrophoblasts: 181 nCPM
  • early primary spermatocytes: 165 nCPM
  • basal keratinocytes: 152 nCPM

Immune cell

  • total PBMC: 110 nTPM
  • basophil: 109 nTPM
  • myeloid DC: 97 nTPM
  • non-classical monocyte: 95 nTPM
  • NK-cell: 93 nTPM
  • T-reg: 93 nTPM

Brain region

  • choroid plexus: 44 nTPM
  • white matter: 30 nTPM
  • hypothalamus: 29 nTPM
  • cerebral cortex: 28 nTPM
  • cerebellum: 28 nTPM
  • spinal cord: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.14
gnomAD pLI
1
gnomAD missense Z
2.27
DepMap mean gene effect
-0.26
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YTHDF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YTHDF2 as an antibody target. Whether an autoantibody or antibody against YTHDF2 could matter depends on whether native YTHDF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YTHDF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YTHDF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/YTHDF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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