Seroatlas · Human Serome Atlas

C5orf22

UPF0489 protein C5orf22

Also known as: CE022_HUMAN, FLJ11193

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q49AR2
Gene: C5orf22
Ensembl: ENSG00000082213
Chromosome: 5
Canonical length: 442 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane

OverviewNCBI Gene

No narrative summary is available for C5orf22 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

442 residues, UniProt reviewed canonical sequence.

>Q49AR2|C5orf22
     1  MSDSAGGRAG LRRYPKLPVW VVEDHQEVLP FIYRAIGSKH LPASNVSFLH FDSHPDLLIP
    61  VNMPADTVFD KETLFGELSI ENWIMPAVYA GHFSHVIWFH PTWAQQIREG RHHFLVGKDT
   121  STTTIRVTST DHYFLSDGLY VPEDQLENQK PLQLDVIMVK PYKLCNNQEE NDAVSSAKKP
   181  KLALEDSENT ASTNCDSSSE GLEKDTATQR SDQTCLEPSC SCSSENQECQ TAASTGEILE
   241  ILKKGKAFVL DIDLDFFSVK NPFKEMFTQE EYKILQELYQ FKKPGTNLTE EDLVDIVDTR
   301  IHQLEDLEAT FADLCDGDDE ETVQRWASNP GMESLVPLVQ SLKKRMEVPD YEMVHQAGLT
   361  CDYSELPHHI STEQEIECLI QSVHYLLKNL PNPTLVTIAR SSLDDYCPSD QVDTIQEKVL
   421  NMLRALYGNL DLQVYAAESP PS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C5orf22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

tongue: 14 nTPM
skeletal muscle: 13 nTPM
pancreas: 10 nTPM
heart muscle: 9.6 nTPM
tonsil: 8.1 nTPM
parathyroid gland: 7.8 nTPM

Single-cell type

mast cells: 60 nCPM
megakaryocytes: 50 nCPM
rod photoreceptor cells: 31 nCPM
cone photoreceptor cells: 29 nCPM
myonuclei: 26 nCPM
bergmann glia: 24 nCPM

Immune cell

basophil: 28 nTPM
non-classical monocyte: 5.2 nTPM
NK-cell: 3.8 nTPM
naive CD8 T-cell: 3.5 nTPM
memory CD4 T-cell: 3.4 nTPM
naive CD4 T-cell: 3.3 nTPM

Brain region

hypothalamus: 9.3 nTPM
white matter: 9.1 nTPM
midbrain: 9 nTPM
cerebral cortex: 8.8 nTPM
basal ganglia: 8.6 nTPM
pons: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: 0.19
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Peptide arginase FlmR/OhkR-like
UPF0489 domain

InteractionsUniProt · HPA

Protein binding partners of C5orf22 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

WBP11

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C5orf22 as an antibody target. Whether an autoantibody or antibody against C5orf22 could matter depends on whether native C5orf22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C5orf22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C5orf22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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