Seroatlas · Human Serome Atlas

GOLPH3

Golgi phosphoprotein 3

Also known as: GOLP3_HUMAN, GOPP1, GPP34, MIDAS, Vps74

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H4A6
Gene: GOLPH3
Ensembl: ENSG00000113384
Chromosome: 5
Canonical length: 298 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may have a regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

298 residues, UniProt reviewed canonical sequence.

>Q9H4A6|GOLPH3
     1  MTSLTQRSSG LVQRRTEASR NAADKERAAG GGAGSSEDDA QSRRDEQDDD DKGDSKETRL
    61  TLMEEVLLLG LKDREGYTSF WNDCISSGLR GCMLIELALR GRLQLEACGM RRKSLLTRKV
   121  ICKSDAPTGD VLLDEALKHV KETQPPETVQ NWIELLSGET WNPLKLHYQL RNVRERLAKN
   181  LVEKGVLTTE KQNFLLFDMT THPLTNNNIK QRLIKKVQEA VLDKWVNDPH RMDRRLLALI
   241  YLAHASDVLE NAFAPLLDEQ YDLATKRVRQ LLDLDPEVEC LKANTNEVLW AVVAAFTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLPH3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 103 nTPM

Expression across tissuesHPA

Tissue

liver: 103 nTPM
gallbladder: 73 nTPM
colon: 72 nTPM
prostate: 71 nTPM
placenta: 64 nTPM
salivary gland: 61 nTPM

Single-cell type

hematopoietic stem cells: 330 nCPM
prostatic glandular cells: 288 nCPM
hepatocytes: 216 nCPM
extravillous trophoblasts: 215 nCPM
monocyte progenitors: 213 nCPM
esophageal apical cells: 212 nCPM

Immune cell

eosinophil: 19 nTPM
naive B-cell: 16 nTPM
T-reg: 13 nTPM
memory B-cell: 12 nTPM
intermediate monocyte: 11 nTPM
non-classical monocyte: 11 nTPM

Brain region

choroid plexus: 48 nTPM
white matter: 45 nTPM
medulla oblongata: 43 nTPM
thalamus: 42 nTPM
cerebellum: 41 nTPM
midbrain: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0.24
gnomAD missense Z: 1.63
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GOLPH3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLPH3 as an antibody target. Whether an autoantibody or antibody against GOLPH3 could matter depends on whether native GOLPH3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLPH3 is annotated at the cell surface, where native GOLPH3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GOLPH3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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