Seroatlas · Human Serome Atlas

MIPOL1

Mirror-image polydactyly gene 1 protein

Also known as: CCDC193, MIPO1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TD10
Gene
MIPOL1
Ensembl
ENSG00000151338
Chromosome
14
Canonical length
442 aa
Protein class
Disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a coiled-coil domain-containing protein. The encoded protein may function as a tumor suppressor. A translocation that results in truncation of the protein encoded by this locus has been associated with mirror-image polydactyly, also known as Laurin-Sandrow Syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

442 residues, UniProt reviewed canonical sequence.

>Q8TD10|MIPOL1
     1  MENWSKDITH SYLEQETTGI NKSTQPDEQL TMNSEKSMHR KSTELVNEIT CENTEWPGQR
    61  STNFQIISSY PDDESVYCTT EKYNVMEHRH NDMHYECMTP CQVTSDSDKE KTIAFLLKEL
   121  DILRTSNKKL QQKLAKEDKE QRKLKFKLEL QEKETEAKIA EKTAALVEEV YFAQKERDEA
   181  VMSRLQLAIE ERDEAIARAK HMEMSLKVLE NINPEENDMT LQELLNRINN ADTGIAIQKN
   241  GAIIVDRIYK TKECKMRITA EEMSALIEER DAALSKCKRL EQELHHVKEQ NQTSANNMRH
   301  LTAENNQERA LKAKLLSMQQ ARETAVQQYK KLEEEIQTLR VYYSLHKSLS QEENLKDQFN
   361  YTLSTYEEAL KNRENIVSIT QQQNEELATQ LQQALTERAN MELQLQHARE ASQVANEKVQ
   421  KLERLVDVLR KKVGTGTMRT VI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MIPOL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
7.9 nTPM

Expression across tissuesHPA

Tissue

  • testis: 7.9 nTPM
  • prostate: 7.2 nTPM
  • parathyroid gland: 6.5 nTPM
  • thyroid gland: 5.4 nTPM
  • ovary: 4.8 nTPM
  • endometrium: 4.4 nTPM

Single-cell type

  • prostatic glandular cells: 1,813 nCPM
  • myonuclei: 269 nCPM
  • early spermatids: 264 nCPM
  • late spermatids: 244 nCPM
  • somatotrophs: 220 nCPM
  • lactotrophs: 205 nCPM

Immune cell

  • neutrophil: 1.5 nTPM
  • basophil: 1.1 nTPM
  • eosinophil: 0.3 nTPM
  • memory B-cell: 0.2 nTPM
  • naive B-cell: 0.2 nTPM
  • NK-cell: 0.2 nTPM

Brain region

  • hypothalamus: 13 nTPM
  • choroid plexus: 13 nTPM
  • basal ganglia: 12 nTPM
  • cerebral cortex: 12 nTPM
  • medulla oblongata: 12 nTPM
  • midbrain: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0
gnomAD missense Z
-0.42
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Mirror-image polydactyly gene 1 protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MIPOL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MIPOL1 as an antibody target. Whether an autoantibody or antibody against MIPOL1 could matter depends on whether native MIPOL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MIPOL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MIPOL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MIPOL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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