Seroatlas · Human Serome Atlas

HGH1

Protein HGH1 homolog

Also known as: Brp16, C8orf30A, C8orf30B, FAM203A, FAM203B, FLJ40907, HGH1_HUMAN, LOC51236

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BTY7
Gene: HGH1
Ensembl: ENSG00000235173
Chromosome: 8
Canonical length: 390 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

No narrative summary is available for HGH1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

390 residues, UniProt reviewed canonical sequence.

>Q9BTY7|HGH1
     1  MGEAGAGAGA SGGPEASPEA EVVKLLPFLA PGARADLQAA AVRHVLALTG CGPGRALLAG
    61  QAALLQALME LAPASAPARD AARALVNLAA DPGLHETLLA ADPGLPARLM GRALDPQWPW
   121  AEEAAAALAN LSREPAPCAA LMAALAAAEP ADSGLERLVR ALCTPGYNAR APLHYLAPLL
   181  SNLSQRPAAR AFLLDPDRCV VQRLLPLTQY PDSSVRRGGV VGTLRNCCFE HRHHEWLLGP
   241  EVDILPFLLL PLAGPEDFSE EEMERLPVDL QYLPPDKQRE PDADIRKMLV EAIMLLTATA
   301  PGRQQVRDQG AYLILRELHS WEPEPDVRTA CEKLIQVLIG DEPERGMENL LEVQVPEDVE
   361  QQLQQLDCRE QEQLERELAP EPWVERATPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HGH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 3.1 nTPM

Expression across tissuesHPA

Tissue

liver: 3.1 nTPM
adrenal gland: 3 nTPM
esophagus: 3 nTPM
pancreas: 2.9 nTPM
stomach: 2.7 nTPM
skeletal muscle: 2.6 nTPM

Single-cell type

late spermatids: 43 nCPM
late primary spermatocytes: 28 nCPM
differentiating spermatogonia: 23 nCPM
esophageal basal cells: 19 nCPM
megakaryocytes: 19 nCPM
migrating cytotrophoblasts: 17 nCPM

Immune cell

naive B-cell: 0.8 nTPM
memory CD8 T-cell: 0.7 nTPM
NK-cell: 0.6 nTPM
memory CD4 T-cell: 0.4 nTPM
naive CD4 T-cell: 0.4 nTPM
gdT-cell: 0.3 nTPM

Brain region

medulla oblongata: 9.5 nTPM
amygdala: 8.7 nTPM
cerebral cortex: 8.5 nTPM
thalamus: 8.5 nTPM
white matter: 8.4 nTPM
hippocampal formation: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0.01
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 19% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Armadillo-like helical
Armadillo-type fold
Protein HGH1 N-terminal
Protein HGH1 C-terminal
Protein Hgh1
Domain of unknown function (DUF383)
Domain of unknown function (DUF384)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HGH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CNS1
TTC4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HGH1 as an antibody target. Whether an autoantibody or antibody against HGH1 could matter depends on whether native HGH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HGH1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HGH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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