Seroatlas · Human Serome Atlas

TSACC

TSSK6-activating co-chaperone protein

Also known as: C1orf182, SIP, SSTK-IP, TSACC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96A04
Gene: TSACC
Ensembl: ENSG00000163467
Chromosome: 1
Canonical length: 125 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Enables protein-folding chaperone binding activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>Q96A04|TSACC
     1  MERHTSHPNR KVPAKEEANA VPLCRAKPSP SYINLQASSP PATFLNIQTT KLPSVDHKPK
    61  ECLGLLECMY ANLQLQTQLA QQQMAVLEHL QASVTQLAPG RGSNNSSLPA LSPNPLLNHL
   121  PQFSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSACC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 879 nTPM

Expression across tissuesHPA

Tissue

testis: 879 nTPM
epididymis: 2.3 nTPM
retina: 2.1 nTPM
liver: 1.7 nTPM
adrenal gland: 1.4 nTPM
spinal cord: 1.3 nTPM

Single-cell type

late spermatids: 29,125 nCPM
late primary spermatocytes: 7,373 nCPM
early spermatids: 6,461 nCPM
early primary spermatocytes: 328 nCPM
cardiomyocytes: 107 nCPM
sertoli cells: 57 nCPM

Immune cell

basophil: 15 nTPM
NK-cell: 1.9 nTPM
plasmacytoid DC: 1.7 nTPM
naive CD4 T-cell: 1.5 nTPM
naive B-cell: 1.4 nTPM
naive CD8 T-cell: 1.3 nTPM

Brain region

white matter: 8 nTPM
cerebellum: 6.2 nTPM
choroid plexus: 5.4 nTPM
medulla oblongata: 5.2 nTPM
pons: 5.2 nTPM
basal ganglia: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0.02
gnomAD missense Z: 0.4
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

protein-folding chaperone binding

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

TSSK6-activating co-chaperone protein
SSTK-interacting protein, TSSK6-activating co-chaperone protein

KeywordsUniProt

Chaperone

InteractionsUniProt · HPA

Protein binding partners of TSACC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HSP70
TSSK6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSACC as an antibody target. Whether an autoantibody or antibody against TSACC could matter depends on whether native TSACC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSACC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSACC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...