Seroatlas · Human Serome Atlas

TSNAXIP1

Translin-associated factor X-interacting protein 1

Also known as: TXI1, TXIP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q2TAA8
Gene
TSNAXIP1
Ensembl
ENSG00000102904
Chromosome
16
Canonical length
658 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

658 residues, UniProt reviewed canonical sequence.

>Q2TAA8|TSNAXIP1
     1  MGGHLSPWPT YTSGQTILQN RKPCSDDYRK RVGSCQQHPF RTAKPQYLEE LENYLRKELL
    61  LLDLGTDSTQ ELRLQPYREI FEFFIEDFKT YKPLLSSIKN AYEGMLAHQR EKIRALEPLK
   121  AKLVTVNEDC NERILAMRAE EKYEISLLKK EKMNLLKLID KKNEEKISLQ SEVTKLRKNL
   181  AEEYLHYLSE RDACKILIAD LNELRYQRED MSLAQSPGIW GEDPVKLTLA LKMTRQDLTR
   241  TQMELNNMKA NFGDVVPRRD FEMQEKTNKD LQEQLDTLRA SYEEVRKEHE ILMQLHMSTL
   301  KERDQFFSEL QEIQRTSTPR PDWTKCKDVV AGGPERWQML AEGKNSDQLV DVLLEEIGSG
   361  LLREKDFFPG LGYGEAIPAF LRFDGLVENK KPSKKDVVNL LKDAWKERLA EEQKETFPDF
   421  FFNFLEHRFG PSDAMAWAYT IFENIKIFHS NEVMSQFYAV LMGKRSENVY VTQKETVAQL
   481  LKEMTNADSQ NEGLLTMEQF NTVLKSTFPL KTEEQIQELM EAGGWHPSSS NADLLNYRSL
   541  FMEDEEGQSE PFVQKLWEQY MDEKDEYLQQ LKQELGIELH EEVTLPKLRG GLMTIDPSLD
   601  KQTVNTYMSQ AFQLPESEMP EEGDEKEEAV VEILQTALER LQVIDIRRVG PREPEPAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSNAXIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • testis: 20 nTPM
  • fallopian tube: 8.1 nTPM
  • pituitary gland: 5.6 nTPM
  • choroid plexus: 5.2 nTPM
  • retina: 3.2 nTPM
  • basal ganglia: 2.9 nTPM

Single-cell type

  • late spermatids: 286 nCPM
  • late primary spermatocytes: 124 nCPM
  • early spermatids: 103 nCPM
  • respiratory ciliated cells: 77 nCPM
  • fallopian tube ciliated cells: 72 nCPM
  • ependymal cells: 63 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 5.9 nTPM
  • midbrain: 4.6 nTPM
  • medulla oblongata: 3.9 nTPM
  • thalamus: 2.9 nTPM
  • basal ganglia: 2.7 nTPM
  • hippocampal formation: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.51
gnomAD pLI
0
gnomAD missense Z
-0.47
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSNAXIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSNAXIP1 as an antibody target. Whether an autoantibody or antibody against TSNAXIP1 could matter depends on whether native TSNAXIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSNAXIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSNAXIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TSNAXIP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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