TSN

Protein identityUniProt · HPA

UniProt accession

Q15631

Gene

TSN

Ensembl

ENSG00000211460

Chromosome

2

Canonical length

228 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Nucleoplasm,Endoplasmic reticulum

OverviewNCBI Gene

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>Q15631|TSN
     1  MSVSEIFVEL QGFLAAEQDI REEIRKVVQS LEQTAREILT LLQGVHQGAG FQDIPKRCLK
    61  AREHFGTVKT HLTSLKTKFP AEQYYRFHEH WRFVLQRLVF LAAFVVYLET ETLVTREAVT
   121  EILGIEPDRE KGFHLDVEDY LSGVLILASE LSRLSVNSVT AGDYSRPLHI STFINELDSG
   181  FRLLNLKNDS LRKRYDGLKY DVKKVEEVVY DLSIRGFNKE TAAACVEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

45 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.45

gnomAD pLI

0.79

gnomAD missense Z

2.11

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulatory ncRNA-mediated post-transcriptional gene silencing
• siRNA processing

Molecular functions

• DNA binding
• endonuclease activity
• hydrolase activity
• identical protein binding
• mRNA binding
• RNA binding
• sequence-specific DNA binding
• single-stranded DNA binding

Cellular components

• cytoplasm
• cytosol
• endoplasmic reticulum
• endoribonuclease complex
• male germ cell nucleus
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Translin family
• Translin, N-terminal
• Translin, C-terminal
• Translin superfamily
• Translin family
• Translin

KeywordsUniProt

• Acetylation
• Cytoplasm
• DNA-binding
• Endonuclease
• Hydrolase
• Nuclease
• Nucleus
• Phosphoprotein
• RNA-binding

InteractionsUniProt · HPA

Protein binding partners of TSN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TSNAX
• GIT2