CCDC92
Coiled-coil domain-containing protein 92
Also known as: CCD92_HUMAN, FLJ22471
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q53HC0
- Gene
- CCDC92
- Ensembl
- ENSG00000119242
- Chromosome
- 12
- Canonical length
- 331 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Vesicles,Centrosome
OverviewNCBI Gene
Enables identical protein binding activity. Predicted to be involved in innate immune response and regulation of defense response to virus. Located in centriole; centrosome; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
331 residues, UniProt reviewed canonical sequence.
>Q53HC0|CCDC92
1 MTSPHFSSYD EGPLDVSMAA TNLENQLHSA QKNLLFLQRE HASTLKGLHS EIRRLQQHCT
61 DLTYELTVKS SEQTGDGTSK SSELKKRCEE LEAQLKVKEN ENAELLKELE QKNAMITVLE
121 NTIKEREKKY LEELKAKSHK LTLLSSELEQ RASTIAYLTS QLHAAKKKLM SSSGTSDASP
181 SGSPVLASYK PAPPKDKLPE TPRRRMKKSL SAPLHPEFEE VYRFGAESRK LLLREPVDAM
241 PDPTPFLLAR ESAEVHLIKE RPLVIPPIAS DRSGEQHSPA REKPHKAHVG VAHRIHHATP
301 PQAQPEVKTL AVDQVNGGKV VRKHSGTDRT VLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CCDC92 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 138 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 138 nTPM
- hippocampal formation: 125 nTPM
- amygdala: 124 nTPM
- hypothalamus: 94 nTPM
- midbrain: 91 nTPM
- spinal cord: 91 nTPM
Single-cell type
- brain excitatory neurons: 132 nCPM
- brain inhibitory neurons: 126 nCPM
- other brain neurons: 110 nCPM
- proximal tubule cells: 94 nCPM
- astrocytes: 93 nCPM
- mast cells: 91 nCPM
Immune cell
- basophil: 1.6 nTPM
- MAIT T-cell: 1.2 nTPM
- memory CD8 T-cell: 1.1 nTPM
- memory CD4 T-cell: 1 nTPM
- naive CD8 T-cell: 0.9 nTPM
- eosinophil: 0.7 nTPM
Brain region
- cerebral cortex: 154 nTPM
- hippocampal formation: 115 nTPM
- amygdala: 103 nTPM
- pons: 103 nTPM
- white matter: 103 nTPM
- basal ganglia: 99 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.62
- gnomAD pLI
- 0.3
- gnomAD missense Z
- 0.31
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CCDC92 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CCDC92 as an antibody target. Whether an autoantibody or antibody against CCDC92 could matter depends on whether native CCDC92 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CCDC92 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CCDC92 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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