Seroatlas · Human Serome Atlas

ZFYVE28

Lateral signaling target protein 2 homolog

Also known as: KIAA1643, lst-2, LST2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HCC9
Gene
ZFYVE28
Ensembl
ENSG00000159733
Chromosome
4
Canonical length
887 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables phosphatidylinositol-3-phosphate binding activity. Involved in negative regulation of epidermal growth factor-activated receptor activity. Located in cytosol and early endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

887 residues, UniProt reviewed canonical sequence.

>Q9HCC9|ZFYVE28
     1  MMNRFRKWLY KPKRSDPQLL ARFYYADEEL NQVAAELDSL DGRKDPQRCT LLVSQFRSCQ
    61  DNVLNIINQI MDECIPQDRA PRDFCVKFPE EIRHDNLAGQ LWFGAECLAA GSIIMNRELE
   121  SMAMRPLAKE LTRSLEDVRG ALRDQALRDL NTYTEKMREA LRHFDVLFAE FELSYVSAMV
   181  PVKSPREYYV QQEVIVLFCE TVERALDFGY LTQDMIDDYE PALMFSIPRL AIVCGLVVYA
   241  DGPLNLDRKV EDMSELFRPF HTLLRKIRDL LQTLTEEELH TLERNLCISQ DVEFPIRADV
   301  QGPAALAPAL SAPLPPEGPL SAKAKDPDAE LACSMQYDDQ ELEQLSRMVH RAGDEMSSLL
   361  SPPIACQSPA HRPGAEGSPG GEASPGRPRL RSGSDEEERV FFMDDVEGTA EALARPESPA
   421  GPFGWAGSTW ADPQEKGQGG PGGAAGISLP ASEKEEDLSN NNLEAEGTDG ASLAGTSSCS
   481  CLDSRLHLDG WEVGADDAET AEMIAHRTGG MKLSATVIFN PKSPTSLDSA VATQEAASEP
   541  VAEGMDGGPH KLSTGATNCL LHSCVCCGSC GDSREDVVER LREKCSPGGV IGASYAAGLA
   601  KASDRAPERQ EEAPPPSEDA SNGREPKAPT SDKCLPHTSG SQVDTASGLQ GEAGVAGQQE
   661  PEARELHAGS PSAHEAPQAL SGSSSSTAGS CSSDKMGPEA APAATHAAPQ ATREKIRSRF
   721  HGSHDLIHRL FVCISGVADQ LQTNYASDLR SILKTLFEVM ATKPETDDKE KLRKVTQTLR
   781  SAALEDCALC QETLSSSELA AKTRDGDFED PPEWVPDEAC GFCTACKAPF TVIRRKHHCR
   841  SCGKIFCSRC SSHSAPLPRY GQVKPVRVCT HCYMFHVTPF YSDKAGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFYVE28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
60 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 60 nTPM
  • cerebral cortex: 17 nTPM
  • basal ganglia: 14 nTPM
  • pituitary gland: 10 nTPM
  • hippocampal formation: 9.3 nTPM
  • small intestine: 8.5 nTPM

Single-cell type

  • retinal ganglion cells: 224 nCPM
  • sertoli cells: 211 nCPM
  • brain excitatory neurons: 210 nCPM
  • choroid plexus epithelial cells: 197 nCPM
  • cone photoreceptor cells: 182 nCPM
  • rod photoreceptor cells: 166 nCPM

Immune cell

  • gdT-cell: 1.9 nTPM
  • T-reg: 1.9 nTPM
  • naive B-cell: 1.8 nTPM
  • naive CD8 T-cell: 1.4 nTPM
  • memory CD8 T-cell: 1.3 nTPM
  • naive CD4 T-cell: 1.3 nTPM

Brain region

  • cerebellum: 137 nTPM
  • cerebral cortex: 69 nTPM
  • medulla oblongata: 53 nTPM
  • pons: 50 nTPM
  • basal ganglia: 48 nTPM
  • midbrain: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.07
gnomAD missense Z
-0.25
DepMap mean gene effect
-0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFYVE28 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFYVE28 as an antibody target. Whether an autoantibody or antibody against ZFYVE28 could matter depends on whether native ZFYVE28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFYVE28 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFYVE28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZFYVE28. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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