Seroatlas · Human Serome Atlas

LTA

Lymphotoxin-alpha

Also known as: LT, TNFB, TNFB_HUMAN, TNFSF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01374
Gene
LTA
Ensembl
ENSG00000226979
Chromosome
6
Canonical length
205 aa
Protein class
Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted secreted proteins
Secretome location
Secreted to blood
Quaternary structure
Homotrimer

OverviewNCBI Gene

The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>P01374|LTA
     1  MTPPERLFLP RVCGTTLHLL LLGLLLVLLP GAQGLPGVGL TPSAAQTARQ HPKMHLAHST
    61  LKPAAHLIGD PSKQNSLLWR ANTDRAFLQD GFSLSNNSLL VPTSGIYFVY SQVVFSGKAY
   121  SPKATSSPLY LAHEVQLFSS QYPFHVPLLS SQKMVYPGLQ EPWLHSMYHG AAFQLTQGDQ
   181  LSTHTDGIPH LVLSPSTVFF GAFAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LTA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
5.4 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 5.4 nTPM
  • testis: 4.1 nTPM
  • lymph node: 2.3 nTPM
  • tonsil: 1.9 nTPM
  • small intestine: 1.8 nTPM
  • cerebellum: 0.8 nTPM

Single-cell type

  • innate lymphoid cells: 2.4 nCPM
  • b-cells: 0.6 nCPM
  • nk-cells: 0.3 nCPM
  • t-cells: 0.3 nCPM
  • astrocytes: 0.2 nCPM
  • bergmann glia: 0.1 nCPM

Immune cell

  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 0.2 nTPM
  • cerebral cortex: 0.1 nTPM
  • midbrain: 0.1 nTPM
  • pons: 0.1 nTPM
  • white matter: 0.1 nTPM
  • amygdala: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LTA.

Disease | AllUniProt

Conditions LTA is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0.2
gnomAD missense Z
1.81
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LTA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LTA as an antibody target. Whether an autoantibody or antibody against LTA could matter depends on whether native LTA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LTA is annotated as secreted, so native LTA circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LTA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LTA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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