CD160
CD160 antigen
Also known as: BY55, BY55_HUMAN, NK1, NK28
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O95971
- Gene
- CD160
- Ensembl
- ENSG00000117281
- Chromosome
- 1
- Canonical length
- 181 aa
- Protein class
- CD markers, Predicted secreted proteins
- Secretome location
- Secreted to blood
- Quaternary structure
- Homomultimer
OverviewNCBI Gene
CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
181 residues, UniProt reviewed canonical sequence.
>O95971|CD160
1 MLLEPGRGCC ALAILLAIVD IQSGGCINIT SSASQEGTRL NLICTVWHKK EEAEGFVVFL
61 CKDRSGDCSP ETSLKQLRLK RDPGIDGVGE ISSQLMFTIS QVTPLHSGTY QCCARSQKSG
121 IRLQGHFFSI LFTETGNYTV TGLKQRQHLE FSHNEGTLSS GFLQEKVWVM LVTSLVALQA
181 LLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CD160 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 15 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 15 nTPM
- spleen: 13 nTPM
- bone marrow: 4.8 nTPM
- liver: 4.7 nTPM
- duodenum: 4.4 nTPM
- small intestine: 4.3 nTPM
Single-cell type
- nk-cells: 112 nCPM
- t-cells: 37 nCPM
- epicardial cells: 30 nCPM
- cardiomyocytes: 28 nCPM
- late spermatids: 19 nCPM
- retinal horizontal cells: 8 nCPM
Immune cell
- gdT-cell: 108 nTPM
- NK-cell: 86 nTPM
- naive CD8 T-cell: 83 nTPM
- total PBMC: 82 nTPM
- memory CD8 T-cell: 73 nTPM
- MAIT T-cell: 45 nTPM
Brain region
- cerebellum: 9 nTPM
- amygdala: 5.1 nTPM
- basal ganglia: 4.9 nTPM
- choroid plexus: 4.9 nTPM
- hippocampal formation: 4.6 nTPM
- cerebral cortex: 4.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.51
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.42
- DepMap mean gene effect
- -0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- adaptive immune response
- angiogenesis
- defense response to Gram-negative bacterium
- innate immune response
- mucosal immune response
- negative regulation of adaptive immune memory response
- negative regulation of angiogenesis
- negative regulation of T cell receptor signaling pathway
- phosphatidylinositol 3-kinase/protein kinase B signal transduction
- positive regulation of endothelial cell apoptotic process
- positive regulation of natural killer cell cytokine production
- positive regulation of natural killer cell degranulation
- positive regulation of natural killer cell mediated cytotoxicity
- positive regulation of type II interferon production
- T cell costimulation
- negative regulation of CD4-positive, alpha-beta T cell costimulation
- positive regulation of natural killer cell mediated immune response to tumor cell
Molecular functions
- kinase binding
- MHC class I protein complex binding
- MHC class I receptor activity
- MHC class Ib receptor activity
- signaling receptor binding
- activating MHC class I receptor activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CD160 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CD160 as an antibody target. Whether an autoantibody or antibody against CD160 could matter depends on whether native CD160 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CD160 is annotated at the cell surface, where native CD160 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Source-annotated serology context
The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.
- CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55.
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