Seroatlas · Human Serome Atlas

RIPPLY1

Protein ripply1

Also known as: RIPP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0D2K3
Gene: RIPPLY1
Ensembl: ENSG00000147223
Chromosome: X
Canonical length: 151 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein similar to a zebrafish protein which acts as a transcriptional repressor in and is required for somite segmentation in zebrafish embryos (PMID: 16326386). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

151 residues, UniProt reviewed canonical sequence.

>Q0D2K3|RIPPLY1
     1  MDSAACAAAA TPVPALALAL APDLAQAPLA LPGLLSPSCL LSSGQEVNGS ERGTCLWRPW
    61  LSSTNDSPRQ MRKLVDLAAG GATAAEVTKA ESKFHHPVRL FWPKSRSFDY LYSAGEILLQ
   121  NFPVQATINL YEDSDSEEEE EDEEQEDEEE K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIPPLY1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 5.4 nTPM

Expression across tissuesHPA

Tissue

liver: 5.4 nTPM
kidney: 2.8 nTPM
choroid plexus: 1.1 nTPM
seminal vesicle: 0.7 nTPM
adrenal gland: 0.4 nTPM
testis: 0.3 nTPM

Single-cell type

hepatocytes: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 1.8 nTPM
hippocampal formation: 0.5 nTPM
cerebral cortex: 0.4 nTPM
white matter: 0.4 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.77
gnomAD pLI: 0.01
gnomAD missense Z: 0.11
DepMap mean gene effect: 0.23
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIPPLY1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TLE5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIPPLY1 as an antibody target. Whether an autoantibody or antibody against RIPPLY1 could matter depends on whether native RIPPLY1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIPPLY1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIPPLY1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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