Prickle/Espinas/Testin
IPR047120
Definition
This entry represents a family of proteins with a LIM-type zinc finger that are found in animals and some fungal species, including Protein prickle (Pk) and Protein espinas (Esn) from Drosophila melanogaster and human Testin (Tes). Pk has been implicated in regulation of cell movement in the planar cell polarity (PCP) pathway PMID:12874125, which requires the conserved Frizzled/Dishevelled (Dsh). Prickle interacts with Dishevelled PMID:15937478, thereby modulating the activity of Frizzled/Dishevelled and the PCP signalling. Two forms of prickle have been identified, namely prickle 1 and prickle 2. These are differentially expressed; prickle 1 is found in fetal heart and haematological malignancies, while prickle 2 is expressed in fetal brain, adult cartilage, pancreatic islet, and some types of tumorous cells PMID:12525887. Esn binds to the seven-pass transmembrane cadherin Flamingo. The interplay elicits repulsion between dendritic branches of sensory neurons PMID:21937715. Tes is a cytoskeleton associated focal adhesion protein that localizes along actin stress fibres, at cell-cell contact areas, and at focal adhesion plaques [[cite:PMID:18696217], [cite:PMID:12571287]]. It plays a role in the regulation of cell proliferation; it may act as a tumour suppressor [[cite:PMID:11420696], [cite:PMID:12571287]].
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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