HMGN2

Protein identityUniProt · HPA

UniProt accession

P05204

Gene

HMGN2

Ensembl

ENSG00000198830

Chromosome

1

Canonical length

90 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli

OverviewNCBI Gene

The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]

Canonical amino-acid sequenceUniProt

90 residues, UniProt reviewed canonical sequence.

>P05204|HMGN2
     1  MPKRKAEGDA KGDKAKVKDE PQRRSARLSA KPAPPKPEPK PKKAPAKKGE KVPKGKKGKA
    61  DAGKEGNNPA ENGDAKTDQA QKAEGAGDAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HMGN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.73

Highest tissue expression

1,073 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HMGN2.

Disease | ImmuneIEDB

Conditions an epitope on HMGN2 was assayed in.

• systemic juvenile rheumatoid arthritis B cell
• systemic lupus erythematosus B cell
• systemic scleroderma B cell

Disease | AutoantibodyPubMed

Conditions in which antibodies against HMGN2 are reported. Each links to that disease's full target list.

• Lupus Erythematosus, Systemic 3

ReferencesPubMed · IEDB

Publications for HMGN2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.46

gnomAD pLI

0.86

gnomAD missense Z

0.03

DepMap mean gene effect

-0.51

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• antimicrobial humoral immune response mediated by antimicrobial peptide
• chromatin organization
• killing of cells of another organism

Molecular functions

• chromatin binding
• nucleosomal DNA binding
• RNA binding

Cellular components

• chromatin
• cytoplasm
• extracellular space
• nucleus

Protein domainsUniProt · Pfam · InterPro

• High mobility group protein HMGN
• HMG14 and HMG17

KeywordsUniProt

• Acetylation
• ADP-ribosylation
• Cytoplasm
• DNA-binding
• Isopeptide bond
• Nucleus
• Phosphoprotein
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of HMGN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NAA40
• TERF2