Seroatlas · Human Serome Atlas

TERF2IP

Telomeric repeat-binding factor 2-interacting protein 1

Also known as: RAP1, TE2IP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NYB0
Gene
TERF2IP
Ensembl
ENSG00000166848
Chromosome
16
Canonical length
399 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables G-rich strand telomeric DNA binding activity and phosphatase binding activity. Involved in several processes, including positive regulation of non-canonical NF-kappaB signal transduction; protection from non-homologous end joining at telomere; and regulation of primary metabolic process. Located in chromosome, telomeric region; cytoplasm; and nuclear body. Part of shelterin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>Q9NYB0|TERF2IP
     1  MAEAMDLGKD PNGPTHSSTL FVRDDGSSMS FYVRPSPAKR RLSTLILHGG GTVCRVQEPG
    61  AVLLAQPGEA LAEASGDFIS TQYILDCVER NERLELEAYR LGPASAADTG SEAKPGALAE
   121  GAAEPEPQRH AGRIAFTDAD DVAILTYVKE NARSPSSVTG NALWKAMEKS SLTQHSWQSL
   181  KDRYLKHLRG QEHKYLLGDA PVSPSSQKLK RKAEEDPEAA DSGEPQNKRT PDLPEEEYVK
   241  EEIQENEEAV KKMLVEATRE FEEVVVDESP PDFEIHITMC DDDPPTPEED SETQPDEEEE
   301  EEEEKVSQPE VGAAIKIIRQ LMEKFNLDLS TVTQAFLKNS GELEATSAFL ASGQRADGYP
   361  IWSRQDDIDL QKDDEDTREA LVKKFGAQNV ARRIEFRKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TERF2IP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
215 nTPM

Expression across tissuesHPA

Tissue

  • hypothalamus: 215 nTPM
  • cerebellum: 214 nTPM
  • cerebral cortex: 188 nTPM
  • basal ganglia: 179 nTPM
  • amygdala: 157 nTPM
  • retina: 156 nTPM

Single-cell type

  • platelets: 399 nCPM
  • müller glia: 326 nCPM
  • retinal bipolar cells: 316 nCPM
  • megakaryocytes: 291 nCPM
  • neutrophils: 276 nCPM
  • early primary spermatocytes: 274 nCPM

Immune cell

  • eosinophil: 102 nTPM
  • naive B-cell: 66 nTPM
  • basophil: 56 nTPM
  • naive CD4 T-cell: 54 nTPM
  • T-reg: 49 nTPM
  • memory CD8 T-cell: 48 nTPM

Brain region

  • hypothalamus: 261 nTPM
  • pons: 191 nTPM
  • midbrain: 187 nTPM
  • white matter: 185 nTPM
  • basal ganglia: 177 nTPM
  • cerebral cortex: 177 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.14
gnomAD pLI
0
gnomAD missense Z
-0.03
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TERF2IP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TERF2IP as an antibody target. Whether an autoantibody or antibody against TERF2IP could matter depends on whether native TERF2IP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TERF2IP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TERF2IP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TERF2IP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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