Tudor domain-containing
IPR050621
Definition
The Tudor domain-containing protein family is involved in various aspects of germ cell development and maintenance of germline integrity. Members of the family participate in the piRNA metabolic process, which is crucial for the repression of transposable elements during meiosis, thereby preventing their mobilization. This process involves the formation of complexes composed of piRNAs and Piwi proteins, which are essential for the methylation and subsequent repression of transposons. The family also plays a role in post-transcriptional regulation of gene expression by binding to specific mRNAs and regulating their translation in cytoplasmic RNA granules. This regulation is necessary for processes such as lens transparency during lens development and spermatogenesis. Additionally, some family members are involved in the assembly of the chromatoid body, the formation of the Balbiani body during oogenesis, and the maturation of the spliceosome and miRNA expression.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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