Seroatlas · Human Serome Atlas

MAEL

Protein maelstrom homolog

Also known as: CT128, FLJ14904, MAEL_HUMAN, SPATA35

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96JY0
Gene
MAEL
Ensembl
ENSG00000143194
Chromosome
1
Canonical length
434 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in male meiotic nuclear division; negative regulation of macromolecule biosynthetic process; and spermatogenesis. Predicted to act upstream of or within several processes, including homologous chromosome pairing at meiosis; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of macromolecule biosynthetic process. Predicted to be located in piP-body. Predicted to be active in P granule and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

434 residues, UniProt reviewed canonical sequence.

>Q96JY0|MAEL
     1  MPNRKASRNA YYFFVQEKIP ELRRRGLPVA RVADAIPYCS SDWALLREEE KEKYAEMARE
    61  WRAAQGKDPG PSEKQKPVFT PLRRPGMLVP KQNVSPPDMS ALSLKGDQAL LGGIFYFLNI
   121  FSHGELPPHC EQRFLPCEIG CVKYSLQEGI MADFHSFINP GEIPRGFRFH CQAASDSSHK
   181  IPISNFERGH NQATVLQNLY RFIHPNPGNW PPIYCKSDDR TRVNWCLKHM AKASEIRQDL
   241  QLLTVEDLVV GIYQQKFLKE PSKTWIRSLL DVAMWDYSSN TRCKWHEEND ILFCALAVCK
   301  KIAYCISNSL ATLFGIQLTE AHVPLQDYEA SNSVTPKMVV LDAGRYQKLR VGSSGFSHFN
   361  SSNEEQRSNT PIGDYPSRAK ISGQNSSVRG RGITRLLESI SNSSSNIHKF SNCDTSLSPY
   421  MSQKDGYKSF SSLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAEL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
149 nTPM

Expression across tissuesHPA

Tissue

  • testis: 149 nTPM
  • placenta: 6.1 nTPM
  • heart muscle: 5.3 nTPM
  • retina: 4 nTPM
  • cerebral cortex: 3.3 nTPM
  • amygdala: 2 nTPM

Single-cell type

  • early spermatids: 1,466 nCPM
  • late primary spermatocytes: 1,237 nCPM
  • late spermatids: 497 nCPM
  • early primary spermatocytes: 328 nCPM
  • oocytes: 244 nCPM
  • differentiating spermatogonia: 133 nCPM

Immune cell

  • plasmacytoid DC: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 3.4 nTPM
  • white matter: 2.6 nTPM
  • basal ganglia: 2.5 nTPM
  • thalamus: 2.4 nTPM
  • hippocampal formation: 2.2 nTPM
  • midbrain: 1.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAEL.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 47 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on MAEL was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0
gnomAD missense Z
0.96
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAEL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAEL as an antibody target. Whether an autoantibody or antibody against MAEL could matter depends on whether native MAEL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAEL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAEL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAEL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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