Trichohyalin-plectin-homology domain

Definition

This entry represents the trichohyalin-plectin-homology domain. This domain can be found in mitostatin (also known as trichoplein keratin filament-binding protein, TCHP) and related proteins [[cite:PMID:15731013], [cite:PMID:18931701]]. Trichoplein keratin filament-binding protein (TCHP) may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. It may regulate K8/K18 filament and desmosome organisation mainly at the apical or peripheral regions of simple epithelial cells PMID:15731013. In human, it acts as a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation PMID:18931701.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• CFAP210
• CFAP45
• CFAP53
• MNS1
• TCHP