Seroatlas · Human Serome Atlas

PSMB8

Proteasome subunit beta type-8

Also known as: beta5i, D6S216E, LMP7, PSB8_HUMAN, PSMB5i, RING10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P28062
Gene: PSMB8
Ensembl: ENSG00000204264
Chromosome: 6
Canonical length: 276 aa
Protein class: Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Cytokinetic bridge

OverviewNCBI Gene

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

276 residues, UniProt reviewed canonical sequence.

>P28062|PSMB8
     1  MALLDVCGAP RGQRPESALP VAGSGRRSDP GHYSFSMRSP ELALPRGMQP TEFFQSLGGD
    61  GERNVQIEMA HGTTTLAFKF QHGVIAAVDS RASAGSYISA LRVNKVIEIN PYLLGTMSGC
   121  AADCQYWERL LAKECRLYYL RNGERISVSA ASKLLSNMMC QYRGMGLSMG SMICGWDKKG
   181  PGLYYVDEHG TRLSGNMFST GSGNTYAYGV MDSGYRPNLS PEEAYDLGRR AIAYATHRDS
   241  YSGGVVNMYH MKEDGWVKVE STDVSDLLHQ YREANQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMB8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 140 nTPM

Expression across tissuesHPA

Tissue

spleen: 140 nTPM
liver: 93 nTPM
small intestine: 87 nTPM
colon: 76 nTPM
adrenal gland: 73 nTPM
lung: 73 nTPM

Single-cell type

enterocytes: 86 nCPM
megakaryocytes: 80 nCPM
breast lactating cells: 75 nCPM
platelets: 73 nCPM
plasma cells: 60 nCPM
enteric transient amplifying cells: 58 nCPM

Immune cell

total PBMC: 156 nTPM
eosinophil: 95 nTPM
neutrophil: 91 nTPM
intermediate monocyte: 88 nTPM
T-reg: 82 nTPM
non-classical monocyte: 79 nTPM

Brain region

medulla oblongata: 3 nTPM
white matter: 2.8 nTPM
spinal cord: 2.4 nTPM
pons: 1.6 nTPM
thalamus: 1.5 nTPM
hypothalamus: 1.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PSMB8.

Disease | AllUniProt

Conditions PSMB8 is implicated in, by any mechanism.

Proteasome-associated autoinflammatory syndrome 1 (PRAAS1) MIM:256040

Disease | GeneticClinVar

21 pathogenic / likely-pathogenic of 277 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Proteosome-associated autoinflammatory syndrome
Proteasome-associated autoinflammatory syndrome 1
PROTEASOME-ASSOCIATED AUTOINFLAMMATORY SYNDROME 1, DIGENIC
PSMB8-related disorder
Autoinflammatory syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.02
gnomAD missense Z: 0.65
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMB8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMB8 as an antibody target. Whether an autoantibody or antibody against PSMB8 could matter depends on whether native PSMB8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMB8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMB8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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