Type 1 protein exporter
IPR039421
Definition
Proteins in this entry are required for type I protein secretion and have an N-terminal ABC transporter type 1 transmembrane domain and a C-terminal P-loop containing nucleoside triphosphate hydrolase domain. The transmembrane domain forms a pore in the inner membrane and the ATP-binding domain is responsible for energy generation. Sequences are mainly from bacteria, but there are homologues from eukaryotes and archaea. Proteins in this entry include the following: Lipid A export ATP-binding/permease protein MsbA, which is required for lipid A and possibly glycerophospholipid transport, and for biogenesis of the outer membrane in bacteria PMID:9575204 Beta-(1-->2)glucan export ATP-binding/permease protein NdvA from nitrogen-fixing bacteria, which is required for beta-(1-->2)glucan export, essential for nodule formation in legume roots PMID:3042754 Iron-sulfur clusters transporter ATM1, a yeast mitochondrial protein that exports Fe/S cluster-containing protein precursors and other mitochondrially synthesized proteins to the cytoplasm PMID:10406803. The mammalian equivalents are the ATP-binding cassette sub-family B members 6, 7, 8 and 9, which are required for the transport of heme and porphyrin from the cytoplasm to the mitochondrion PMID:17006453 Leukotoxin translocation ATP-binding protein LktB, required for leukotoxin export inMannheimia haemolytica Multidrug resistance protein 1, which exports xenobiotics, such as cytotoxic drugs, out of cells leading to tumour cell resistance to multiple drugs PMID:2876781. The bacterial equivalents include multidrug resistance-like ATP-binding protein MdlA Alpha-hemolysin translocation ATP-binding protein HlyB fromE. coli, a component of the ABC transporter complex HlyBD required for the export of hemolysin PMID:2112747 Phosphatidylcholine translocator ABCB4, required for lipid secretion in the bile, transporting phosphatidylcholine from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes PMID:7957936 Bile salt export pump, required for the secretion of bile salts into the canaliculus of hepatocytes PMID:17264802 Antigen peptide transporter 1, which is required for the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules PMID:8955196 P-glycoprotein 14 which exports polar lipids into the developing pharyngeal cuticle to protect against xenobiotic insult PMID:37930961. PGP-14 has an internal duplication and two copies of the constituent domains.
11 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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