Seroatlas · Human Serome Atlas

TAF1A

TATA box-binding protein-associated factor RNA polymerase I subunit A

Also known as: SL1, TAF1A_HUMAN, TAFI48

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15573
Gene: TAF1A
Ensembl: ENSG00000143498
Chromosome: 1
Canonical length: 450 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

450 residues, UniProt reviewed canonical sequence.

>Q15573|TAF1A
     1  MSDFSEELKG PVTDDEEVET SVLSGAGMHF PWLQTYVETV AIGGKRRKDF AQTTSACLSF
    61  IQEALLKHQW QQAAEYMYSY FQTLEDSDSY KRQAAPEIIW KLGSEILFYH PKSNMESFNT
   121  FANRMKNIGV MNYLKISLQH ALYLLHHGML KDAKRNLSEA ETWRHGENTS SREILINLIQ
   181  AYKGLLQYYT WSEKKMELSK LDKDDYAYNA VAQDVFNHSW KTSANISALI KIPGVWDPFV
   241  KSYVEMLEFY GDRDGAQEVL TNYAYDEKFP SNPNAHIYLY NFLKRQKAPR SKLISVLKIL
   301  YQIVPSHKLM LEFHTLLRKS EKEEHRKLGL EVLFGVLDFA GCTKNITAWK YLAKYLKNIL
   361  MGNHLAWVQE EWNSRKNWWP GFHFSYFWAK SDWKEDTALA CEKAFVAGLL LGKGCRYFRY
   421  ILKQDHQILG KKIKRMKRSV KKYSIVNPRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 6 nTPM

Expression across tissuesHPA

Tissue

lymph node: 6 nTPM
testis: 5.9 nTPM
ovary: 5.2 nTPM
tonsil: 5.2 nTPM
urinary bladder: 4.9 nTPM
thyroid gland: 4.7 nTPM

Single-cell type

gastric progenitor cells: 23 nCPM
lactotrophs: 20 nCPM
oocytes: 18 nCPM
somatotrophs: 18 nCPM
foveolar cells: 17 nCPM
microglia: 17 nCPM

Immune cell

naive B-cell: 7.3 nTPM
memory B-cell: 5.2 nTPM
plasmacytoid DC: 5.2 nTPM
MAIT T-cell: 4.7 nTPM
naive CD8 T-cell: 4.1 nTPM
naive CD4 T-cell: 3.3 nTPM

Brain region

white matter: 6.6 nTPM
hypothalamus: 6.4 nTPM
medulla oblongata: 5.8 nTPM
cerebellum: 5.3 nTPM
pons: 5.3 nTPM
basal ganglia: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 1
DepMap mean gene effect: -0.74
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

TATA box-binding protein-associated factor RNA polymerase I subunit A, chordata
TATA box-binding protein-associated factor RNA polymerase I subunit A
SL1/TIF-IB Complex Component
TAF RNA Polymerase I subunit A

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAF1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAF1A as an antibody target. Whether an autoantibody or antibody against TAF1A could matter depends on whether native TAF1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAF1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAF1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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