Seroatlas · Human Serome Atlas

TAF1B

TATA box-binding protein-associated factor RNA polymerase I subunit B

Also known as: RAF1B, RAFI63, SL1, TAF1B_HUMAN, TAFI63

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53T94
Gene: TAF1B
Ensembl: ENSG00000115750
Chromosome: 2
Canonical length: 588 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

588 residues, UniProt reviewed canonical sequence.

>Q53T94|TAF1B
     1  MDLEEAEEFK ERCTQCAAVS WGLTDEGKYY CTSCHNVTER YQEVTNTDLI PNTQIKALNR
    61  GLKKKNNTEK GWDWYVCEGF QYILYQQAEA LKNLGVGPEL KNDVLHNFWK RYLQKSKQAY
   121  CKNPVYTTGR KPTVLEDNLS HSDWASEPEL LSDVSCPPFL ESGAESQSDI HTRKPFPVSK
   181  ASQSETSVCS GSLDGVEYSQ RKEKGIVKMT MPQTLAFCYL SLLWQREAIT LSDLLRFVEE
   241  DHIPYINAFQ HFPEQMKLYG RDRGIFGIES WPDYEDIYKK TVEVGTFLDL PRFPDITEDC
   301  YLHPNILCMK YLMEVNLPDE MHSLTCHVVK MTGMGEVDFL TFDPIAKMAK TVKYDVQAVA
   361  IIVVVLKLLF LLDDSFEWSL SNLAEKHNEK NKKDKPWFDF RKWYQIMKKA FDEKKQKWEE
   421  ARAKYLWKSE KPLYYSFVDK PVAYKKREMV VNLQKQFSTL VESTATAGKK SPSSFQFNWT
   481  EEDTDRTCFH GHSLQGVLKE KGQSLLTKNS LYWLSTQKFC RCYCTHVTTY EESNYSLSYQ
   541  FILNLFSFLL RIKTSLLHEE VSLVEKKLFE KKYSVKRKKS RSKKVRRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 14 nTPM
kidney: 12 nTPM
placenta: 12 nTPM
tonsil: 12 nTPM
lymph node: 11 nTPM
thymus: 11 nTPM

Single-cell type

ependymal cells: 155 nCPM
thyrotrophs: 154 nCPM
extravillous trophoblasts: 97 nCPM
early primary spermatocytes: 82 nCPM
esophageal apical cells: 82 nCPM
renal connecting tubule cells: 81 nCPM

Immune cell

intermediate monocyte: 16 nTPM
memory CD8 T-cell: 14 nTPM
myeloid DC: 13 nTPM
non-classical monocyte: 13 nTPM
MAIT T-cell: 12 nTPM
gdT-cell: 12 nTPM

Brain region

choroid plexus: 17 nTPM
midbrain: 15 nTPM
cerebellum: 14 nTPM
hypothalamus: 14 nTPM
white matter: 13 nTPM
cerebral cortex: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 0.77
DepMap mean gene effect: -0.93
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleolus
nucleoplasm
nucleus
RNA polymerase transcription factor SL1 complex
RNA polymerase I core factor complex

Protein domainsUniProt · Pfam · InterPro

Transcription initiation factor Rrn7, Zinc-finger
RNA polymerase I transcription initiation factor TAF1B/Rrn7
Rrn7/TAF1B, C-terminal cyclin domain
Rrn7/TAF1B, N-terminal cyclin domain
Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7
Rrn7/TAF1B, N-terminal cyclin domain
Rrn7/TAF1B, C-terminal cyclin domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAF1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAF1B as an antibody target. Whether an autoantibody or antibody against TAF1B could matter depends on whether native TAF1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAF1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAF1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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