Seroatlas · Human Serome Atlas

CYTH3

Cytohesin-3

Also known as: ARNO3, CYH3_HUMAN, cytohesin-3, GRP1, PSCD3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43739
Gene
CYTH3
Ensembl
ENSG00000008256
Chromosome
7
Canonical length
400 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

400 residues, UniProt reviewed canonical sequence.

>O43739|CYTH3
     1  MDEDGGGEGG GVPEDLSLEE REELLDIRRR KKELIDDIER LKYEIAEVMT EIDNLTSVEE
    61  SKTTQRNKQI AMGRKKFNMD PKKGIQFLIE NDLLQSSPED VAQFLYKGEG LNKTVIGDYL
   121  GERDEFNIKV LQAFVELHEF ADLNLVQALR QFLWSFRLPG EAQKIDRMME AFASRYCLCN
   181  PGVFQSTDTC YVLSFAIIML NTSLHNHNVR DKPTAERFIA MNRGINEGGD LPEELLRNLY
   241  ESIKNEPFKI PEDDGNDLTH TFFNPDREGW LLKLGGGRVK TWKRRWFILT DNCLYYFEYT
   301  TDKEPRGIIP LENLSIREVE DPRKPNCFEL YNPSHKGQVI KACKTEADGR VVEGNHVVYR
   361  ISAPSPEEKE EWMKSIKASI SRDPFYDMLA TRKRRIANKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYTH3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 42 nTPM
  • placenta: 30 nTPM
  • heart muscle: 28 nTPM
  • adipose tissue: 28 nTPM
  • thyroid gland: 27 nTPM
  • breast: 26 nTPM

Single-cell type

  • melanocytes: 576 nCPM
  • mast cells: 263 nCPM
  • pericytes: 213 nCPM
  • sertoli cells: 192 nCPM
  • fibro-adipogenic progenitors: 188 nCPM
  • endometrial luminal cells: 187 nCPM

Immune cell

  • MAIT T-cell: 2.5 nTPM
  • NK-cell: 1.5 nTPM
  • memory CD8 T-cell: 1 nTPM
  • gdT-cell: 0.9 nTPM
  • plasmacytoid DC: 0.8 nTPM
  • naive CD8 T-cell: 0.6 nTPM

Brain region

  • cerebral cortex: 28 nTPM
  • hippocampal formation: 23 nTPM
  • white matter: 22 nTPM
  • amygdala: 21 nTPM
  • thalamus: 21 nTPM
  • basal ganglia: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.72
gnomAD missense Z
2.57
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CYTH3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYTH3 as an antibody target. Whether an autoantibody or antibody against CYTH3 could matter depends on whether native CYTH3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYTH3 is annotated at the cell surface, where native CYTH3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CYTH3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CYTH3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...