Seroatlas · Human Serome Atlas

SYCE3

Synaptonemal complex central element protein 3

Also known as: C22orf41, SYCE3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A1L190
Gene: SYCE3
Ensembl: ENSG00000217442
Chromosome: 22
Canonical length: 88 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Golgi apparatus
Quaternary structure: Homotetramer

OverviewNCBI Gene

Predicted to be involved in reciprocal meiotic recombination; spermatogenesis; and synaptonemal complex assembly. Predicted to act upstream of or within positive regulation of apoptotic process; positive regulation of developmental process; and positive regulation of reproductive process. Predicted to be located in chromosome and nucleus. Predicted to be active in central element. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

88 residues, UniProt reviewed canonical sequence.

>A1L190|SYCE3
     1  MDDADPEERN YDNMLKMLSD LNKDLEKLLE EMEKISVQAT WMAYDMVVMR TNPTLAESMR
    61  RLEDAFVNCK EEMEKNWQEL LHETKQRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYCE3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 133 nTPM

Expression across tissuesHPA

Tissue

testis: 133 nTPM
kidney: 2.5 nTPM
midbrain: 2.4 nTPM
basal ganglia: 2.3 nTPM
amygdala: 2 nTPM
cerebral cortex: 1.8 nTPM

Single-cell type

late primary spermatocytes: 877 nCPM
early spermatids: 441 nCPM
early primary spermatocytes: 398 nCPM
differentiating spermatogonia: 145 nCPM
late spermatids: 66 nCPM
undifferentiated spermatogonia: 20 nCPM

Immune cell

neutrophil: 4.4 nTPM
myeloid DC: 1.1 nTPM
eosinophil: 0.8 nTPM
classical monocyte: 0.7 nTPM
intermediate monocyte: 0.6 nTPM
non-classical monocyte: 0.5 nTPM

Brain region

medulla oblongata: 1.6 nTPM
midbrain: 1.4 nTPM
thalamus: 1.1 nTPM
hypothalamus: 0.9 nTPM
white matter: 0.9 nTPM
cerebral cortex: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0.6
gnomAD missense Z: 0.74
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Synaptonemal complex central element protein 3
Synaptonemal complex central element protein 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYCE3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYCE3 as an antibody target. Whether an autoantibody or antibody against SYCE3 could matter depends on whether native SYCE3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYCE3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYCE3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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