Seroatlas · Human Serome Atlas

SIX6OS1

Protein SIX6OS1

Also known as: C14orf39, S6OS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N1H7
Gene
SIX6OS1
Ensembl
ENSG00000179008
Chromosome
14
Canonical length
587 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

Involved in homologous chromosome pairing at meiosis. Predicted to be located in chromosome. Predicted to be active in central element. Implicated in primary ovarian insufficiency 18 and spermatogenic failure 52. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

587 residues, UniProt reviewed canonical sequence.

>Q8N1H7|SIX6OS1
     1  MNDSLFVSLD RLLLEFVFQY EQDISTKEEM IQRINKCCED IKENKVTICR IHETINATDE
    61  EIDHYCKHSE EIKDNCRNWK PTCDVFRKHE DYMQDQFTVY QGTVEKDKEM YHDYICQYKE
   121  VLKQYQLKYS ETPFSREYYE KKREHEEIQS RVLACTEQLK MNETIFMKFR VPAPFPSLTK
   181  WTLNIVNLRC ETQDILKHAS NLTKSSSELK KEVDEMEIEI NYLNQQISRH NETKALSETL
   241  EEKNKNTENR KELKERIFGK DEHVLTLNKT QSSQLFLPYE SQKLVRPIKM HSSEPRVADI
   301  KEESSAKQSK LANIDFRQKE NDTQIFNDSA VDNHSKCSHI TTITSSQKFM QVRLLTPQKQ
   361  SNSNQWSEKG DKDAEYGDKG TVRQVRESKC TSQAIYTEHF GKSVENDSDE VEERAENFPR
   421  TSEIPIFLGT PKAVKAPESL EKIKFPKTPP FEINRNRNAV PEVQTEKESP GLSFLMSYTS
   481  RSPGLNLFDS SVFDTEISSD QFNEHYSARN LNPLSSEQEI GNLLEKPEGE DGFTFSFPSD
   541  TSTHTFGAGK DDFSFPFSFG QGQNSIPSSS LKGFSSSSQN TTQFTFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIX6OS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • testis: 10 nTPM
  • pituitary gland: 4.5 nTPM
  • salivary gland: 4.4 nTPM
  • tongue: 3.4 nTPM
  • skeletal muscle: 2.8 nTPM
  • retina: 2.5 nTPM

Single-cell type

  • early primary spermatocytes: 248 nCPM
  • lactotrophs: 217 nCPM
  • thyrotrophs: 203 nCPM
  • myonuclei: 188 nCPM
  • pituitary stem cells: 172 nCPM
  • somatotrophs: 132 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 6.2 nTPM
  • choroid plexus: 1.9 nTPM
  • basal ganglia: 0.4 nTPM
  • medulla oblongata: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM
  • hippocampal formation: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SIX6OS1.

Disease | AllUniProt

Conditions SIX6OS1 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0
DepMap mean gene effect
0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Six6 opposite strand transcript 1
  • Six6 opposite strand transcript 1 family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SIX6OS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIX6OS1 as an antibody target. Whether an autoantibody or antibody against SIX6OS1 could matter depends on whether native SIX6OS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIX6OS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SIX6OS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SIX6OS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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