SYCE2
Synaptonemal complex central element protein 2
Also known as: CESC1, SYCE2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6PIF2
- Gene
- SYCE2
- Ensembl
- ENSG00000161860
- Chromosome
- 19
- Canonical length
- 218 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
- Quaternary structure
- Homodimer
OverviewNCBI Gene
The protein encoded by this gene is part of the synaptonemal complex formed between homologous chromosomes during meiotic prophase. The encoded protein associates with SYCP1 and SYCE1 and is found only where chromosome cores are synapsed. [provided by RefSeq, Dec 2012]
Canonical amino-acid sequenceUniProt
218 residues, UniProt reviewed canonical sequence.
>Q6PIF2|SYCE2
1 MERQGVDVPH VKCKDQEPQP LGESKEHPRW EENCEEEAGG GPASASCQLT VLEGKSGLYF
61 SSLDSSIDIL QKRAQELIEN INKSRQKDHA LMTNFRNSLK TKVSDLTEKL EERIYQIYND
121 HNKIIQEKLQ EFTQKMAKIS HLETELKQVC HSVETVYKDL CLQPEQSLRL RWGPDHSRGK
181 SPPRPGNSQP PDVFVSSVAE TTSQATASEV QTNRDGECLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SYCE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.6
- Highest tissue expression
- 25 nTPM
Expression across tissuesHPA
Tissue
- testis: 25 nTPM
- bone marrow: 3.1 nTPM
- cerebellum: 2.5 nTPM
- liver: 1.7 nTPM
- thymus: 1.7 nTPM
- cerebral cortex: 1.3 nTPM
Single-cell type
- early primary spermatocytes: 417 nCPM
- late primary spermatocytes: 118 nCPM
- differentiating spermatogonia: 61 nCPM
- cardiomyocytes: 25 nCPM
- epicardial cells: 25 nCPM
- early spermatids: 24 nCPM
Immune cell
- NK-cell: 2.7 nTPM
- eosinophil: 0.7 nTPM
- memory CD4 T-cell: 0.2 nTPM
- T-reg: 0.2 nTPM
- gdT-cell: 0.1 nTPM
- myeloid DC: 0.1 nTPM
Brain region
- white matter: 4.3 nTPM
- cerebellum: 4.1 nTPM
- cerebral cortex: 3.1 nTPM
- basal ganglia: 2.7 nTPM
- pons: 2.7 nTPM
- medulla oblongata: 2.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.63
- gnomAD pLI
- 0.28
- gnomAD missense Z
- 0.93
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Synaptonemal complex central element protein 2
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SYCE2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SYCE2 as an antibody target. Whether an autoantibody or antibody against SYCE2 could matter depends on whether native SYCE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SYCE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SYCE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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